Determination of cysteine in a pharmaceutical formulation by flow injection analysis with a chemiluminescence detector

被引：96
|
作者：
Lau, CW [1 ]
Qin, XJ [1 ]
Liang, HY [1 ]
Lu, HZ [1 ]
机构：
[1] Fudan Univ, Sch Pharm, Shanghai 200032, Peoples R China
来源：
ANALYTICA CHIMICA ACTA | 2004年 / 514卷 / 01期
关键词：
cysteine; chemiluminescence; flow injection; pharmaceutical formulation;
D O I：
10.1016/j.aca.2004.01.007
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A simple and convenient flow injection-chemiluminescence (FI-CL) method for the determination of cysteine is reported, based on a fast and strong CL in a basic luminol-cysteine-NaIO4 solution. The linear range was 1.0 x 10(-8) to 1.0 X 10(-6) M with a detection limit (3s) of 5 x 10(-9) M, which was 100 times more sensitive than previously reported CL methods. Singlet oxygen, hydroxyl radical and hydrogen peroxide were suggested to be produced in this reaction and were responsible for the CL of cysteine. This simple method has been successfully applied for the determination of cysteine in a pharmaceutical formulation. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：45 / 49
页数：5
相关论文
共 50 条
  • [1] Sensitive determination of nanogram levels of diacerein in a pharmaceutical formulation by flow injection chemiluminescence analysis
    Han-Chun Yao
    Xiao-Feng Yang
    Hua Li
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2007, 54 (04) : 949 - 956
  • [2] Direct Determination of Azathioprine in Human Fluids and Pharmaceutical Formulation Using Flow Injection Chemiluminescence Analysis
    Wang, Jianbo
    Zhao, Pan
    Han, Suqin
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2012, 59 (02) : 239 - 244
  • [3] Flow-Injection Lucigenin–Cu(III) Complex Chemiluminescence Determination of Cysteine and Glutathione in Pharmaceutical Formulations
    Zahoor Ahmed
    Mohammad Yaqoob
    Muhammad Asghar
    Samar Ali
    Nusrat Munawar
    Abdul Kabir Khan Achakzai
    Abdul Nabi
    Journal of Analytical Chemistry, 2021, 76 : 466 - 475
  • [4] Determination of cefmetazole residue at pharmaceutical manufacturing facilities by chemiluminescence flow injection analysis
    Fukutsu, Naoto
    Konse, Tomonori
    Kawasaki, Takao
    Saito, Koichi
    Nakazawa, Hiroyuki
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2006, 41 (02) : 599 - 602
  • [5] THE DETERMINATION OF THE PRESERVATIVE, CHLOROCRESOL, IN A PHARMACEUTICAL FORMULATION BY FLOW-INJECTION ANALYSIS
    BLOOMFIELD, MS
    PREBBLE, KA
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1992, 10 (10-12) : 775 - 778
  • [6] Silver nanoparticles enhanced flow injection chemiluminescence determination of gatifloxacin in pharmaceutical formulation and spiked urine sample
    Wabaidur, Saikh Mohammad
    Alamb, Seikh Mafiz
    Alothman, Zeid A.
    Mohsin, Kazi
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2015, 144 : 170 - 175
  • [7] Flow injection-chemiluminescence determination of propranolol in pharmaceutical preparations
    Townshend, A
    Pulgarín, JAM
    Pardo, MTA
    ANALYTICA CHIMICA ACTA, 2003, 488 (01) : 81 - 88
  • [8] Flow injection-chemiluminescence determination of puerarin in pharmaceutical preparations
    Zhang, QL
    Myint, A
    Liu, LJ
    Ge, XW
    Cui, H
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2004, 36 (03) : 587 - 592
  • [9] Flow-Injection Lucigenin-Cu(III) Complex Chemiluminescence Determination of Cysteine and Glutathione in Pharmaceutical Formulations
    Ahmed, Zahoor
    Yaqoob, Mohammad
    Asghar, Muhammad
    Ali, Samar
    Munawar, Nusrat
    Achakzai, Abdul Kabir Khan
    Nabi, Abdul
    JOURNAL OF ANALYTICAL CHEMISTRY, 2021, 76 (04) : 466 - 475
  • [10] Flow injection analysis with simple chemiluminescence detector for hypoxanthine
    Yagiuda, K
    Hemmi, A
    Sakamura, K
    Ito, S
    Asano, Y
    Hayashi, K
    Karube, I
    DENKI KAGAKU, 1995, 63 (12): : 1148 - 1153
12345