Synthesis of arylsulfonyl-quinones and arylsulfonyl-1,4-diols as FabH inhibitors: Pd-catalyzed direct C-sulfone formation by C-S coupling of quinones with arylsulfonyl chloride

被引：39
作者：
Ge, Bingyang [1 ]
Wang, Dawei [1 ]
Dong, Weifu [1 ]
Ma, Piming [1 ]
Li, Yongliang [1 ]
Ding, Yuqiang [1 ]
机构：
[1] Jiangnan Univ, Sch Chem & Mat Engn, Minist Educ, Key Lab Food Colloids & Biotechnol, Wuxi 214122, Jiangsu, Peoples R China
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 40期
基金：
中国国家自然科学基金;
关键词：
C-sulfone; Coupling; Quinones; Sulfonyl-1,4-diols; FabH inhibitors; H BOND ACTIVATION; PROTEIN SYNTHASE-III; DIRECT ORTHO ARYLATION; 1,4-NAPHTHOQUINONE DERIVATIVES; CONJUGATE ADDITION; ANTIFUNGAL; INDOLES; WATER;
D O I：
10.1016/j.tetlet.2014.08.023
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Pd-catalyzed direct C-sulfone formation by C-S coupling of quinones with arylsulfonyl chloride has been developed. This methodology provides an effective, convenient method for the synthesis of aryl-sulfonyl-quinones and arylsulfonyl-1,4-diols, which are potent inhibitors of FabH. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5443 / 5446
页数：4
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