Soil Amendments That Slow Cancer Growth

被引：0

作者：

Isacke, Clare M. ^{[1
]}

Barcellos-Hoff, Mary Helen ^{[2
,3
]}

机构：

[1] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England

[2] NYU, Sch Med, Dept Radiat Oncol, New York, NY 10016 USA

[3] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA

来源：

CANCER DISCOVERY | 2014年 / 4卷 / 06期

关键词：

ANGIOGENESIS;

D O I：

10.1158/2159-8290.CD-14-0416

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The recognition that the tumor microenvironment contributes to tumor survival, growth, and response to therapy provides the rationale for considering it a therapeutic target. The article by Alspach and colleagues in this issue provides evidence that p38MAPK acts posttranscriptionally to promote the tumor-permissive secretory phenotype of both cancer-associated and senescent fibroblasts, and that p38MAPK inhibitors already in clinical trials have significant therapeutic potential.

引用

页码：637 / 639

页数：3

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