A Reduced SNARE Model for Membrane Fusion

被引：125
|
作者：
Marsden, Hana Robson [1 ]
Elbers, Nina A. [1 ]
Bomans, Paid H. H. [2 ,3 ]
Sommerdijk, Nico A. J. M. [2 ,3 ]
Kros, Alexander [1 ]
机构：
[1] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands
[2] Eindhoven Univ Technol, Lab Mat & Interface Chem, NL-5600 MB Eindhoven, Netherlands
[3] Eindhoven Univ Technol, Soft Matter CryoTEM Res Unit, Dept Chem Engn & Chem, NL-5600 MB Eindhoven, Netherlands
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 13期
关键词：
coiled coils; lipopeptides; liposomes; membrane fusion; SNARE proteins; VESICLE FUSION; COILED-COIL; LIPIDS;
D O I：
10.1002/anie.200804493
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Let's get together: A minimal model system was developed to mimic the SNARE-proteinmediated fusion of biological membranes (see picture). Fusion between two populations of liposomes is controlled by a pair of complementary lipidated oligopeptides that form noncovalent coiled-coil complexes and thereby force the membranes into close proximity to promote fusion. The model system displays the key characteristics of in vivo fusion events. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2330 / 2333
页数：4
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