A Reduced SNARE Model for Membrane Fusion

被引：125
|
作者：
Marsden, Hana Robson [1 ]
Elbers, Nina A. [1 ]
Bomans, Paid H. H. [2 ,3 ]
Sommerdijk, Nico A. J. M. [2 ,3 ]
Kros, Alexander [1 ]
机构：
[1] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands
[2] Eindhoven Univ Technol, Lab Mat & Interface Chem, NL-5600 MB Eindhoven, Netherlands
[3] Eindhoven Univ Technol, Soft Matter CryoTEM Res Unit, Dept Chem Engn & Chem, NL-5600 MB Eindhoven, Netherlands
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 13期
关键词：
coiled coils; lipopeptides; liposomes; membrane fusion; SNARE proteins; VESICLE FUSION; COILED-COIL; LIPIDS;
D O I：
10.1002/anie.200804493
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Let's get together: A minimal model system was developed to mimic the SNARE-proteinmediated fusion of biological membranes (see picture). Fusion between two populations of liposomes is controlled by a pair of complementary lipidated oligopeptides that form noncovalent coiled-coil complexes and thereby force the membranes into close proximity to promote fusion. The model system displays the key characteristics of in vivo fusion events. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2330 / 2333
页数：4
相关论文
共 50 条
  • [21] SNAREs and SNARE regulators in membrane fusion and exocytosis
    J. E. Gerst
    Cellular and Molecular Life Sciences CMLS, 1999, 55 : 707 - 734
  • [22] Phase Specific Membrane Fusion with SNARE Mimetics
    Kubsch, Bastian
    Robinson, Tom
    Kliesch, Torben-Tobias
    Janshoff, Andreas
    Lipowsky, Reinhard
    Dimova, Rumiana
    BIOPHYSICAL JOURNAL, 2017, 112 (03) : 77A - 77A
  • [23] Are SNARE proteins necessary and sufficient for membrane fusion?
    Coorssen, JR
    Blank, PS
    Kolosova, I
    Backlund, P
    Zimmerberg, J
    MOLECULAR BIOLOGY OF THE CELL, 1999, 10 : 219A - 219A
  • [24] What is the role of SNARE proteins in membrane fusion?
    Duman, JG
    Forte, JG
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2003, 285 (02): : C237 - C249
  • [25] Hemifusion in SNARE-mediated membrane fusion
    Xu, YB
    Zhang, F
    Su, ZL
    McNew, JA
    Shin, YK
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2005, 12 (05) : 417 - 422
  • [26] SNARE-mediated membrane fusion in autophagy
    Wang, Yongyao
    Li, Linsen
    Hou, Chen
    Lai, Ying
    Long, Jiangang
    Liu, Jiankang
    Zhong, Qing
    Diao, Jiajie
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2016, 60 : 97 - 104
  • [27] SNARE proteins:: a central role in membrane fusion
    Seagar, M
    Quetglas, S
    Iborra, C
    Lévêque, C
    M S-MEDECINE SCIENCES, 2001, 17 (05): : 669 - 674
  • [28] Hemifusion in SNARE-mediated membrane fusion
    Yibin Xu
    Fan Zhang
    Zengliu Su
    James A McNew
    Yeon-Kyun Shin
    Nature Structural & Molecular Biology, 2005, 12 : 417 - 422
  • [29] SNAREs and SNARE regulators in membrane fusion and exocytosis
    Gerst, JE
    CELLULAR AND MOLECULAR LIFE SCIENCES, 1999, 55 (05) : 707 - 734
  • [30] One SNARE complex is sufficient for membrane fusion
    van den Bogaart, Geert
    Holt, Matthew G.
    Bunt, Gertrude
    Riedel, Dietmar
    Wouters, Fred S.
    Jahn, Reinhard
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2010, 17 (03) : 358 - U129
12345