A Reduced SNARE Model for Membrane Fusion

被引：125

作者：

Marsden, Hana Robson ^{[1
]}

Elbers, Nina A. ^{[1
]}

Bomans, Paid H. H. ^{[2
,3
]}

Sommerdijk, Nico A. J. M. ^{[2
,3
]}

Kros, Alexander ^{[1
]}

机构：

[1] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands

[2] Eindhoven Univ Technol, Lab Mat & Interface Chem, NL-5600 MB Eindhoven, Netherlands

[3] Eindhoven Univ Technol, Soft Matter CryoTEM Res Unit, Dept Chem Engn & Chem, NL-5600 MB Eindhoven, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 13期

关键词：

coiled coils; lipopeptides; liposomes; membrane fusion; SNARE proteins; VESICLE FUSION; COILED-COIL; LIPIDS;

D O I：

10.1002/anie.200804493

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Let's get together: A minimal model system was developed to mimic the SNARE-proteinmediated fusion of biological membranes (see picture). Fusion between two populations of liposomes is controlled by a pair of complementary lipidated oligopeptides that form noncovalent coiled-coil complexes and thereby force the membranes into close proximity to promote fusion. The model system displays the key characteristics of in vivo fusion events. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2330 / 2333

页数：4

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