Are we closer to having drugs to treat muscle wasting disease?

被引：71

作者：

Morley, John E. ^{[1
,2
]}

von Haehling, Stephan ^{[3
]}

Anker, Stefan D. ^{[3
,4
]}

机构：

[1] St Louis Univ, Sch Med, Div Geriatr Med, St Louis, MO 63104 USA

[2] St Louis Univ, Sch Med, Div Endocrinol, St Louis, MO 63104 USA

[3] Campus Virchow Klinikum, Charite Med Sch, Dept Cardiol, Berlin, Germany

[4] Univ Med Ctr Gottingen, Dept Innovat Clin Trials, Gottingen, Germany

来源：

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE | 2014年 / 5卷 / 02期

关键词：

CHRONIC HEART-FAILURE; QUALITY-OF-LIFE; LEAN BODY-MASS; DOUBLE-BLIND; PHYSICAL FUNCTION; OLDER MEN; MEGESTROL-ACETATE; NUTRITIONAL SUPPLEMENT; LIMITED MOBILITY; CANCER CACHEXIA;

D O I：

10.1007/s13539-014-0149-7

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The two most common muscle wasting diseases in adults are sarcopenia and cachexia. Despite differences in their pathophysiology, it is believed that both conditions are likely to respond to drugs that increase muscle mass and muscle strength. The current gold standard in this regard is exercise training. This article provides an overview of candidate drugs to treat muscle wasting disease that are available or in development. Drugs highlighted here include ghrelin agonists, selective androgen receptor molecules, megestrol acetate, activin receptor antagonists, espindolol, and fast skeletal muscle troponin inhibitors.

引用

页码：83 / 87

页数：5

共 73 条

[1] MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: A multicenter, randomized, placebo-controlled phase IIb study [J].

Adunsky, Abraham ;

Chandler, Julie ;

Heyden, Norman ;

Lutkiewicz, Jeannine ;

Scott, Boyd B. ;

Berd, Yuliya ;

Liu, Nancy ;

Papanicolaou, Dimitris A. .

ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2011, 53 (02) :183-189

[2] Muscle wasting disease: a proposal for a new disease classification [J].

Anker, Stefan D. ;

Coats, Andrew J. S. ;

Morley, John E. ;

Rosano, Giuseppe ;

Bernabei, Roberto ;

von Haehling, Stephan ;

Kalantar-Zadeh, Kamyar .

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 2014, 5 (01) :1-3

[3] The potential of ghrelin in the treatment of cancer cachexia [J].

Argiles, Josep M. ;

Stemmler, Britta .

EXPERT OPINION ON BIOLOGICAL THERAPY, 2013, 13 (01) :67-76

[4] Are there any benefits of exercise training in cancer cachexia? [J].

Argiles, Josep M. ;

Busquets, Silvia ;

Lopez-Soriano, Francisco J. ;

Costelli, Paola ;

Penna, Fabio .

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 2012, 3 (02) :73-76

[5] Consensus on Cachexia Definitions [J].

Argiles, Josep M. ;

Anker, Stefan D. ;

Evans, William J. ;

Morley, John E. ;

Fearon, Ken C. H. ;

Strasser, Florian ;

Muscaritoli, Maurizio ;

Baracos, Vicky E. .

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2010, 11 (04) :229-230

[6] A single ascending-dose study of muscle regulator ace-031 in healthy volunteers [J].

Attie, Kenneth M. ;

Borgstein, Niels G. ;

Yang, Yijun ;

Condon, Carolyn H. ;

Wilson, Dawn M. ;

Pearsall, Amelia E. ;

Kumar, Ravi ;

Willins, Debbie A. ;

Seehra, Jas S. ;

Sherman, Matthew L. .

MUSCLE & NERVE, 2013, 47 (03) :416-423

[7] Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group [J].

Bauer, Juergen ;

Biolo, Gianni ;

Cederholm, Tommy ;

Cesari, Matteo ;

Cruz-Jentoft, Alfonso J. ;

Morley, John E. ;

Phillips, Stuart ;

Sieber, Cornel ;

Stehle, Peter ;

Teta, Daniel ;

Visvanathan, Renuka ;

Volpi, Elena ;

Boirie, Yves .

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2013, 14 (08) :542-559

[8] Defining a role for non-satellite stem cells in the regulation of muscle repair following exercise [J].

Boppart, Marni D. ;

De Lisio, Michael ;

Zou, Kai ;

Huntsman, Heather D. .

FRONTIERS IN PHYSIOLOGY, 2013, 4

[9] New Strategies for the Concurrent Strength-, Power-, and Endurance-Training Prescription in Elderly Individuals [J].

Cadore, Eduardo L. ;

Izquierdo, Mikel .

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2013, 14 (08) :623-624

[10] Effect of Long-Acting Testosterone Treatment on Functional Exercise Capacity, Skeletal Muscle Performance, Insulin Resistance, and Baroreflex Sensitivity in Elderly Patients With Chronic Heart Failure A Double-Blind, Placebo-Controlled, Randomized Study [J].

Caminiti, Giuseppe ;

Volterrani, Maurizio ;

Iellamo, Ferdinando ;

Marazzi, Giuseppe ;

Massaro, Rosalba ;

Miceli, Marco ;

Mammi, Caterina ;

Piepoli, Massimo ;

Fini, Massimo ;

Rosano, Giuseppe M. C. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 54 (10) :919-927

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