Association of types of dietary fats and all-cause and cause-specific mortality: A prospective cohort study and meta-analysis of prospective studies with 1,164,029 participants

被引:54
作者
Mazidi, Mohsen [1 ]
Mikhailidis, Dimitri P. [2 ]
Sattar, Naveed [3 ]
Toth, Peter P. [4 ,5 ]
Judd, Suzanne [6 ]
Blaha, Michael J. [4 ]
Hernandez, Adrian V. [7 ,8 ]
Penson, Peter E. [9 ,10 ]
Banach, Maciej [11 ,12 ,13 ]
机构
[1] Kings Coll London, St Thomas Hosp, Dept Twin Res & Genet Epidemiol, London, England
[2] Univ Coll London UCL, Sch Med, Dept Clin Biochem, Royal Free Campus, London, England
[3] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland
[4] Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Baltimore, MD USA
[5] CGH Med Ctr, Prevent Cardiol, Sterling, IL USA
[6] Univ Alabama Birmingham, Dept Biostat, Birmingham, AL USA
[7] Univ Connecticut, Sch Pharm, Hlth Outcomes Policy & Evidence Synth HOPES Grp, Storrs, CT USA
[8] Univ Peruana Ciencias Aplicadas UPC, Sch Med, Lima, Peru
[9] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Liverpool, Merseyside, England
[10] Liverpool Ctr Cardiovasc Sci, Liverpool, Merseyside, England
[11] Med Univ Lodz, Chair Nephrol & Hypertens, Dept Hypertens, Lodz, Poland
[12] Polish Mothers Mem Hosp Res Inst PMMHRI, Lodz, Poland
[13] Univ Zielona Gora, Cardiovasc Res Ctr, Zielona Gora, Poland
关键词
Dietary fats; Coronary heart disease; Stroke; Mortality; Diabetes; Meta-analysis; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; FOLLOW-UP; SATURATED FAT; RISK; MEN; ACIDS; NUTRITION; CANCER;
D O I
10.1016/j.clnu.2020.03.028
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Associations between dietary fats and mortality are unclear. Methods: We evaluated the relationship between quartiles of total fat, mono-unsaturated (MUFA), polyunsaturated (PUFA) and saturated fatty acid (SFA) consumption, and all-cause, coronary heart disease (CHD), stroke, and type 2 diabetes (T2D)-associated mortality in 24,144 participants from the National Health and Nutrition Examination Surveys (NHANES) 1999-2010. We added our results to a meta-analysis based on searches until November 2018. Results: In fully adjusted Cox-proportional hazard models in our prospective study, there was an inverse association between total fat (HR: 0.90, 95% confidence interval 0.82, 0.99, Q4 vs Q1) and PUFA (0.81, 0.78-0.84) consumption and all-cause mortality, whereas SFA were associated with the increased mortality (1.08, 1.04-1.11). In the meta-analysis of 29 prospective cohorts (n = 1,164,029) we found a significant inverse association between total fat (0.89, 0.82-0.97), MUFA (0.94, 0.89-0.99) and PUFA (0.89, 0.84-0.94) consumption and all-cause mortality. No association was observed between total fat and CVD (0.93, 0.80-1.08) or CHD mortality (1.03 0.99-1.09). A significant association between SFA intake and CHD mortality (1.10, 1.01-1.21) was observed. Neither MUFA nor PUFA were associated with CVD or CHD mortality. Inverse associations were observed between MUFA (0.80, 0.67-0.96) and PUFA (0.84, 0.80-0.90) intakes and stroke mortality. Conclusions: We showed differential associations of total fat, MUFA and PUFA with all-cause mortality, but not CVD or CHD mortalities. SFA was associated with higher all-cause mortality in NHANES and with CHD mortality in our meta-analysis. The type of fat intake appears to be associated with important health outcomes. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
引用
收藏
页码:3677 / 3686
页数:10
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