Direct asymmetric aldol reactions in brine using novel sulfonamide catalyst

被引：37
作者：
Miura, Tsuyoshi [1 ]
Yasaku, Yumi [1 ]
Koyata, Naka [1 ]
Murakami, Yasuoki [1 ]
Imai, Nobuyuki [1 ]
机构：
[1] Chiba Inst Sci, Fac Pharm, Chiba 2880025, Japan
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 22期
基金：
日本学术振兴会;
关键词：
WATER-COMPATIBLE ORGANOCATALYSTS; DIRECT SYN-ALDOL; ENANTIOSELECTIVE CYCLOPROPANATION; ORGANIC-REACTIONS; AMINO-ACID; DISULFONAMIDE LIGAND; ALIPHATIC-KETONES; HIGHLY EFFICIENT; SMALL PEPTIDES; AQUEOUS-MEDIA;
D O I：
10.1016/j.tetlet.2009.03.053
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Direct asymmetric aldol reactions of aldehydes with ketones in the presence of a catalytic amount of sulfonamide 4 and trifluoroacetic acid afforded the corresponding anti-aldol products in moderate to excellent yields with 85-93% ee. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2632 / 2635
页数：4
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