Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies

被引：149

作者：

Cavalli, Giulio ^{[1
,2
]}

Dinarello, Charles A. ^{[1
,3
]}

机构：

[1] Univ Colorado Denver, Dept Med, Aurora, CO 80045 USA

[2] IRCCS, San Raffaele Sci Inst, Div Internal Med & Clin Immunol, Milan, Italy

[3] Radboud Univ Nijmegen, Dept Internal Med, Med Ctr, NL-6525 ED Nijmegen, Netherlands

来源：

RHEUMATOLOGY | 2015年 / 54卷 / 12期

基金：

美国国家卫生研究院;

关键词：

interleukin-1; IL-1; alpha; beta; rheumatoid arthritis; autoinflammatory syndromes; cardiovascular disease; diabetes; anakinra; canakinumab; JUVENILE IDIOPATHIC ARTHRITIS; RECEPTOR ANTAGONIST ANAKINRA; ERDHEIM-CHESTER DISEASE; FAMILIAL MEDITERRANEAN FEVER; ONCOGENE-INDUCED SENESCENCE; ACUTE MYOCARDIAL-INFARCTION; ACUTE GOUTY-ARTHRITIS; NECROSIS-FACTOR-ALPHA; RHEUMATOID-ARTHRITIS; DOUBLE-BLIND;

D O I：

10.1093/rheumatology/kev269

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The inflammatory cytokines IL-1 alpha and IL-1 beta orchestrate local and systemic inflammatory responses underlying a broad spectrum of diseases. Three agents for reducing IL-1 activities are currently available. Anakinra is a recombinant form of the naturally occurring IL-1 receptor antagonist. Anakinra binds to the IL-1 receptor and prevents the activity of IL-1 alpha and IL-1 beta. The soluble decoy receptor rilonacept and the neutralizing mAb canakinumab block IL-1 beta. A mAb directed against the IL-1 receptor and a neutralizing anti-human IL-1 alpha are in clinical trials. The availability of therapies specifically targeting IL-1 unveiled the pathological role of IL-1-mediated inflammation in a broadening list of diseases. Conditions effectively treated with agents blocking IL-1 range from classic rheumatic diseases, such as RA and gout, to autoinflammatory syndromes, such as systemic JIA and FMF. However, IL-1 antagonism is also effective against highly prevalent inflammatory diseases, namely cardiovascular diseases and type 2 diabetes, conditions that are frequently encountered as co-morbidities in patients with rheumatic diseases. Thereby, IL-1 inhibition has the potential to lift the burden of disease for patients with rheumatic conditions, but also to provide clinical benefits beyond the efficacy on osteoarticular manifestations.

引用

页码：2134 / 2144

页数：11

共 152 条

[1] Effects of Interleukin-1 Blockade With Anakinra on Adverse Cardiac "Remodeling and Heart Failure After Acute Myocardial Infarction [from the Virginia Commonwealth. University-Anakinra Remodeling Trial (2) (VCU-ART2) Pilot Study] [J].

Abbate, Antonio ;

Van Tassel, Benjamin Wallace ;

Biondi-Zoccai, Giuseppe ;

Kontos, Michael Christopher ;

Grizzard, John Dallas ;

Spillman, Debra Whittaker ;

Oddi, Claudia ;

Roberts, Charlotte Susan ;

Melchior, Ryan David ;

Mueller, George Herman ;

Abouzaki, Nayef Antar ;

Rengel, Lenore Rosemary ;

Varma, Amit ;

Gambill, Michael Lucas ;

Falcao, Raquel Appa ;

Voelkel, Norbert Felix ;

Dinarello, Charles Anthony ;

Vetrovec, George Wayne .

AMERICAN JOURNAL OF CARDIOLOGY, 2013, 111 (10) :1394-1400

[2]

Abbate A, 2012, BIODRUGS, V26, P217, DOI 10.2165/11631570-000000000-00000

[3] Interleukin-1β modulation using a genetically engineered antibody prevents adverse cardiac remodelling following acute myocardial infarction in the mouse [J].

Abbate, Antonio ;

Van Tassell, Benjamin W. ;

Seropian, Ignacio M. ;

Toldo, Stefano ;

Robati, Roshanak ;

Varma, Amit ;

Salloum, Fadi N. ;

Smithson, Lisa ;

Dinarello, Charles A. .

EUROPEAN JOURNAL OF HEART FAILURE, 2010, 12 (04) :319-322

[4] NALP3 forms an IL-lβ-Processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder [J].

Agostini, L ;

Martinon, F ;

Burns, K ;

McDermott, MF ;

Hawkins, PN ;

Tschopp, J .

IMMUNITY, 2004, 20 (03) :319-325

[5] Anakinra efficacy in a Caucasian patient with renal AA amyloidosis secondary to cryopyrin-associated periodic syndrome [J].

Ait-Abdesselam, Tassadit ;

Lequerre, Thierry ;

Legallicier, Bruno ;

Francois, Arnaud ;

Loet, Xavier Le ;

Vittecoq, Olivier .

JOINT BONE SPINE, 2010, 77 (06) :616-617

[6] An Autoinflammatory Disease with Deficiency of the Interleukin-1-Receptor Antagonist [J].

Aksentijevich, Ivona ;

Masters, Seth L. ;

Ferguson, Polly J. ;

Dancey, Paul ;

Frenkel, Joost ;

van Royen-Kerkhoff, Annet ;

Laxer, Ron ;

Tedgard, Ulf ;

Cowen, Edward W. ;

Pham, Tuyet-Hang ;

Booty, Matthew ;

Estes, Jacob D. ;

Sandler, Netanya G. ;

Plass, Nicole ;

Stone, Deborah L. ;

Turner, Maria L. ;

Hill, Suvimol ;

Butman, John A. ;

Schneider, Rayfel ;

Babyn, Paul ;

El-Shanti, Hatem I. ;

Pope, Elena ;

Barron, Karyl ;

Bing, Xinyu ;

Laurence, Arian ;

Lee, Chyi-Chia R. ;

Chapelle, Dawn ;

Clarke, Gillian I. ;

Ohson, Kamal ;

Nicholson, Marc ;

Gadina, Massimo ;

Yang, Barbara ;

Korman, Benjamin D. ;

Gregersen, Peter K. ;

van Hagen, P. Martin ;

Hak, A. Elisabeth ;

Huizing, Marjan ;

Rahman, Proton ;

Douek, Daniel C. ;

Remmers, Elaine F. ;

Kastner, Daniel L. ;

Goldbach-Mansky, Raphaela .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (23) :2426-2437

[7] Efficacy and safety of the human anti-IL-1beta monoclonal antibody canakinumab in rheumatoid arthritis: results of a 12-week, phase II, dose-finding study [J].

Alten, Rieke ;

Gomez-Reino, Juan ;

Durez, Patrick ;

Beaulieu, Andre ;

Sebba, Anthony ;

Krammer, Gerhard ;

Preiss, Ralph ;

Arulmani, Udayasankar ;

Widmer, Albert ;

Gitton, Xavier ;

Kellner, Herbert .

BMC MUSCULOSKELETAL DISORDERS, 2011, 12

[8] Topical Interleukin 1 Receptor Antagonist for Treatment of Dry Eye Disease [J].

Amparo, Francisco ;

Dastjerdi, Mohammad H. ;

Okanobo, Andre ;

Ferrari, Giulio ;

Smaga, Leila ;

Hamrah, Pedram ;

Jurkunas, Ula ;

Schaumberg, Debra A. ;

Dana, Reza .

JAMA OPHTHALMOLOGY, 2013, 131 (06) :715-723

[9] Anakinra is a possible alternative in the treatment and prevention of acute attacks of pseudogout in end-stage renal failure [J].

Announ, Nadia ;

Palmer, Gaby ;

Gueme, Pierre-Andre ;

Gabay, Cem .

JOINT BONE SPINE, 2009, 76 (04) :424-426

[10] Rationale and efficacy of interleukin-1 targeting in Erdheim-Chester disease [J].

Aouba, Achille ;

Georgin-Lavialle, Sophie ;

Pagnoux, Christian ;

Silva, Nicolas Martin ;

Renand, Amedee ;

Galateau-Salle, Francoise ;

Le Toquin, Sophie ;

Bensadoun, Henri ;

Larousserie, Frederique ;

Silvera, Stephane ;

Provost, Nicole ;

Candon, Sophie ;

Seror, Raphaele ;

de Menthon, Mathilde ;

Hermine, Olivier ;

Guillevin, Loic ;

Bienvenu, Boris .

BLOOD, 2010, 116 (20) :4070-4076

← 1 2 3 4 5 6 7 8 9 10 →