Putative biomarkers and therapeutic targets associated with radiation resistance

被引：12
作者：
Skvortsov, Sergej [1 ]
Debbage, Paul [2 ]
Cho, William C. S. [3 ]
Lukas, Peter [1 ]
Skvortsova, Ira [1 ]
机构：
[1] Med Univ Innsbruck, Dept Therapeut Radiol & Oncol, Lab Expt & Translat Res Radiat Oncol EXTRO Lab, A-6020 Innsbruck, Austria
[2] Med Univ Innsbruck, Dept Anat Histol & Embryol, A-6020 Innsbruck, Austria
[3] Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China
来源：
EXPERT REVIEW OF PROTEOMICS | 2014年 / 11卷 / 02期
关键词：
biomarker; cancer stem cells; intracellular signaling; proteomics; radiation therapy; HEAT-SHOCK PROTEINS; NASOPHARYNGEAL CARCINOMA RESPONSE; BREAST-CANCER; INITIATING CELLS; PROSTATE-CANCER; KAPPA-B; RAC1; IDENTIFICATION; RADIOTHERAPY; PROTEOMICS;
D O I：
10.1586/14789450.2014.893194
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Radiation therapy plays an important role in the management of malignant tumors, however, the problem of radiation resistance resulting in tumor recurrences after treatment is still unsolved. The emergence of novel biomarkers to predict cancer cell insensitivity to ionizing radiation could help to improve therapy results in cancer patients receiving radiation therapy. The proteomic approach could be effectively used to identify proteins associated with cancer radiation resistance. It is generally believed that radiation resistance could be associated with cancer stem cell persistence within the tumor. Therefore, determination of the molecular characteristics of cancer stem cells could provide additional possibilities to discover novel biomarkers to predict radiation resistance in cancer patients. This review addresses proteome-based findings that could be used for further biomarker identification and preclinical and clinical validation.
引用
收藏
页码：207 / 214
页数：8
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