STAT3 induces muscle stem cell differentiation by interaction with myoD

被引：43

作者：

Yang, Yanping ^{[2
]}

Xu, Ying ^{[2
]}

Li, Wei ^{[2
]}

Wang, Guanjun ^{[2
]}

Song, Yanqiu ^{[2
]}

Yang, Guozi ^{[2
]}

Han, Xue ^{[2
]}

Du, Zhonghua ^{[2
]}

Sun, Luguo ^{[1
]}

Ma, Kewei ^{[2
]}

机构：

[1] Jilin Univ, Dept Mol Biol, Coll Basic Med, Changchun 130021, Peoples R China

[2] Jilin Univ, Dept Hematol & Oncol, First Hosp, Changchun 130021, Peoples R China

来源：

CYTOKINE | 2009年 / 46卷 / 01期

关键词：

stat3; MyoD; LIF; C2C12; cell; AG490; TRANSCRIPTIONAL CONTROL; C-MYC; ACTIVATION; EXPRESSION; MYOGENESIS; FOS; GROWTH; BCL-2; MEF2;

D O I：

10.1016/j.cyto.2008.12.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Signal transducers and activators of transcription (STAT) family proteins transduce pivotal biological effects of various cytokines and hormones. STAT3 proteins are known to play a central role in the regulation of growth, differentiation, and survival of many types of cells. However, the function of STAT3 in myogenesis still remains largely unknown. We now provided direct evidence that STAT3 could induce myogenic differentiation and this effect might be mediated by interaction with MyoD-the essential transcription factor during myogenic differentiation. Furthermore, leukemia inhibitory factor (LIF) might be the upstream factor which activated JAK2/STAT3 pathway to stimulate muscle cell differentiation. Taken together, these results provide a molecular basis for further understanding of the muscle regeneration mechanism. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：137 / 141

页数：5

共 39 条

[31] MyoD meets its maker [J].

Rawls, A ;

Olson, EN .

CELL, 1997, 89 (01) :5-8

[32] The molecular regulation of myogenesis [J].

Sabourin, LA ;

Rudnicki, MA .

CLINICAL GENETICS, 2000, 57 (01) :16-25

[33] Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis [J].

Shirogane, T ;

Fukada, T ;

Muller, JMM ;

Shima, DT ;

Hibi, M ;

Hirano, T .

IMMUNITY, 1999, 11 (06) :709-719

[34] INHIBITION OF MYOGENIC DIFFERENTIATION IN PROLIFERATING MYOBLASTS BY CYCLIN D1-DEPENDENT KINASE [J].

SKAPEK, SX ;

RHEE, J ;

SPICER, DB ;

LASSAR, AB .

SCIENCE, 1995, 267 (5200) :1022-1024

[35] Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site [J].

Spitz, F ;

Demignon, J ;

Porteu, A ;

Kahn, A ;

Concordet, JP ;

Daegelen, D ;

Maire, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (24) :14220-14225

[36] Critical proliferation-independent window for basic fibroblast growth factor repression of myogenesis via the p42/p44 MAPK signaling pathway [J].

Tortorella, LL ;

Milasincic, DJ ;

Pilch, PF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (17) :13709-13717

[37] The modulation of caveolin-1 expression controls satellite cell activation during muscle repair [J].

Volonte, D ;

Liu, YH ;

Galbiati, F .

FASEB JOURNAL, 2004, 18 (14) :237-+

[38] SERIAL PASSING AND DIFFERENTIATION OF MYOGENIC CELLS ISOLATED FROM DYSTROPHIC MOUSE MUSCLE [J].

YAFFE, D ;

SAXEL, O .

NATURE, 1977, 270 (5639) :725-727

[39] STAT3-mediated astrocyte differentiation from mouse fetal neuroepithelial cells by mouse oncostatin M [J].

Yanagisawa, M ;

Nakashima, K ;

Taga, T .

NEUROSCIENCE LETTERS, 1999, 269 (03) :169-172

← 1 2 3 4 →