STAT3 induces muscle stem cell differentiation by interaction with myoD

被引：43

作者：

Yang, Yanping ^{[2
]}

Xu, Ying ^{[2
]}

Li, Wei ^{[2
]}

Wang, Guanjun ^{[2
]}

Song, Yanqiu ^{[2
]}

Yang, Guozi ^{[2
]}

Han, Xue ^{[2
]}

Du, Zhonghua ^{[2
]}

Sun, Luguo ^{[1
]}

Ma, Kewei ^{[2
]}

机构：

[1] Jilin Univ, Dept Mol Biol, Coll Basic Med, Changchun 130021, Peoples R China

[2] Jilin Univ, Dept Hematol & Oncol, First Hosp, Changchun 130021, Peoples R China

来源：

CYTOKINE | 2009年 / 46卷 / 01期

关键词：

stat3; MyoD; LIF; C2C12; cell; AG490; TRANSCRIPTIONAL CONTROL; C-MYC; ACTIVATION; EXPRESSION; MYOGENESIS; FOS; GROWTH; BCL-2; MEF2;

D O I：

10.1016/j.cyto.2008.12.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Signal transducers and activators of transcription (STAT) family proteins transduce pivotal biological effects of various cytokines and hormones. STAT3 proteins are known to play a central role in the regulation of growth, differentiation, and survival of many types of cells. However, the function of STAT3 in myogenesis still remains largely unknown. We now provided direct evidence that STAT3 could induce myogenic differentiation and this effect might be mediated by interaction with MyoD-the essential transcription factor during myogenic differentiation. Furthermore, leukemia inhibitory factor (LIF) might be the upstream factor which activated JAK2/STAT3 pathway to stimulate muscle cell differentiation. Taken together, these results provide a molecular basis for further understanding of the muscle regeneration mechanism. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：137 / 141

页数：5

共 39 条

[1] Transcriptional activation of the p21WAF1,CIP1,SDI1 gene by interleukin-6 type cytokines -: A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells [J].

Bellido, T ;

O'Brien, CA ;

Roberson, PK ;

Manolagas, SC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (33) :21137-21144

[2] Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins [J].

Black, BL ;

Olson, EN .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1998, 14 :167-196

[3] Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway [J].

Bonni, A ;

Sun, Y ;

NadalVicens, M ;

Bhatt, A ;

Frank, DA ;

Rozovsky, I ;

Stahl, N ;

Yancopoulos, GD ;

Greenberg, ME .

SCIENCE, 1997, 278 (5337) :477-483

[4] Stat3 as an oncogene [J].

Bromberg, JF ;

Wrzeszczynska, MH ;

Devgan, G ;

Zhao, YX ;

Pestell, RG ;

Albanese, C ;

Darnell, JE .

CELL, 1999, 98 (03) :295-303

[5]

Bromberg JF, 2001, BIOESSAYS, V23, P161, DOI 10.1002/1521-1878(200102)23:2<161::AID-BIES1023>3.0.CO

[6]

2-0

[7]

CHULMAN J, 2005, BIOCHIM BIOPHYS ACTA, V1743, P187

[8]

COFFER P, 1995, ONCOGENE, V10, P985

[9]

Dominov JA, 2001, DEV DYNAM, V220, P18, DOI 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1088>3.0.CO

[10]

2-#

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