Assessment of CD11b and CD11/18 integrin expression on leukocytes of dogs with atopic dermatitis

被引：1

作者：

Taszkun, Iwona ^{[1
]}

机构：

[1] Univ Life Sci Lublin, Subdept Clin Diagnost & Vet Dermatol, Dept & Clin Internal Med, Fac Vet Med, PL-20612 Lublin, Poland

来源：

BULLETIN OF THE VETERINARY INSTITUTE IN PULAWY | 2014年 / 58卷 / 01期

关键词：

dogs; atopic dermatitis; integrins; CD11b; CD11/18; flow cytometry; CANINE; NEUTROPHILS; RECEPTORS; ADHESION;

D O I：

10.2478/bvip-2014-0016

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Cytometric analysis was performed in order to detect the expression of surface molecules CD11b and CD11/18 on lymphocytes, granulocytes, and monocytes of peripheral blood of dogs with atopic dermatitis (AD) complicated by purulent dermatitis. The percentage of peripheral blood lymphocytes with CD11b and CD11/18 was found to be significantly higher (P < 0.05) in dogs with AD than in healthy dogs. The percentage of granulocytes expressing CD11b molecule was significantly lower in dogs with complicated AD compared to healthy dogs and dogs with uncomplicated AD. The expression of CD11b and CD11/18 integrin on monocytes of dogs with complicated AD depended on the severity of symptoms and was higher in dogs with deep purulent dermatitis. It was concluded that the expression of CD11b and CD11/18 integrin on leukocytes of dogs with AD depends on the stage of the disease.

引用

页码：99 / 103

页数：5

共 20 条

[11] Interventions for atopic dermatitis in dogs: a systematic review of randomized controlled trials [J].

Olivry, Thierry ;

Foster, Aiden P. ;

Mueller, Ralf S. ;

McEwan, Neil A. ;

Chesney, Christopher ;

Williams, Hywel C. .

VETERINARY DERMATOLOGY, 2010, 21 (01) :4-22

[12]

Prélaud P, 1998, REV MED VET-TOULOUSE, V149, P1057

[13] The effect of ex vivo refrigerated storage and cell preservation solution (Cyto-Chex II™) on CD11b expression and oxidative burst activity of dog neutrophils [J].

Ruaux, CG ;

Williams, DA .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2000, 74 (1-2) :59-69

[14] Reactivity of cross-reacting monoclonal antibodies with canine leukocytes, platelets and erythrocytes [J].

Schuberth, Hans-Joachim ;

Kucinskiene, Gintare ;

Chu, Rea-Min ;

Faldyna, Martin .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2007, 119 (1-2) :47-55

[15] Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation [J].

van Spriel, AB ;

Leusen, JHW ;

van Egmond, M ;

Dijkman, HBPM ;

Assmann, KJM ;

Mayadas, TN ;

van de Winkel, JGJ .

BLOOD, 2001, 97 (08) :2478-2486

[16]

Warzecha Z., 2010, GASTROENTEROL POL, V17, P227

[17] ATOPIC SKIN-DISEASE - A REVIEW AND A RECONSIDERATION OF DIAGNOSTIC-CRITERIA [J].

WILLEMSE, T .

JOURNAL OF SMALL ANIMAL PRACTICE, 1986, 27 (11) :771-778

[18] Studies of canine leucocyte antigens: A significant advance in canine immunology [J].

Williams, DL .

VETERINARY JOURNAL, 1997, 153 (01) :31-39

[19] Leukocyte mobilization to skin lesions, determination of cell surface receptors (CD11b/CD18) and phagocytic capacities of neutrophils in dogs with chronic deep pyoderma [J].

Wisselink, MA ;

vanKessel, KPM ;

Willemse, T .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1997, 57 (3-4) :179-186

[20]

Zebrowska A, 2006, ALERG ASTMA IMMUNOL, V11, P199

← 1 2 →