One-step diketopiperazine synthesis using phase transfer catalysis

被引：26
作者：
O'Reilly, Elaine [1 ]
Lestini, Elena [1 ]
Baiducci, Daniele [1 ]
Paradisi, Francesca [1 ]
机构：
[1] UCD, Sch Chem & Chem Biol, Ctr Synth & Chem Biol, Dublin 4, Ireland
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 15期
关键词：
Diketopiperazine; Chloroacetamide; Phase transfer catalyst; TEBA; DERIVATIVES; ACIDS; PIPERAZINE-2,5-DIONES; MECHANISM;
D O I：
10.1016/j.tetlet.2009.01.146
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient one-step procedure is described for the synthesis of a number of symmetrical 1,4-disubstituted piperazine-2,5-diones under phase transfer conditions. The reactions are carried out at room temperature, starting from a suitable N-chloroacetamide in the presence of an aqueous Solution of sodium hydroxide. Piperazine-2,5-diones were obtained with excellent selectivity in yields of up to 90%. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1748 / 1750
页数：3
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