Synthesis and biological efficacy of novel piperazine analogues bearing quinoline and pyridine moieties

被引：8

作者：

Al-Ghorbani, M. ^{[1
]}

Rekha, N. D. ^{[2
]}

Ranganatha, V. Lakshmi ^{[1
,3
]}

Prashanth, T. ^{[1
,4
]}

Veerabasappagowda, T. ^{[2
]}

Khanum, S. A. ^{[1
]}

机构：

[1] Univ Mysore, Dept Chem, Yuvarajas Coll, Mysore, Karnataka, India

[2] JSS Coll Arts Commerce & Sci, Dept Studies Biotechnol, Mysore, Karnataka, India

[3] St Philomenas Coll, PG Dept Chem, Mysore 570015, Karnataka, India

[4] Natl Inst Engn, Dept Chem, Mysore 570008, Karnataka, India

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2015年 / 41卷 / 05期

关键词：

piperazine analogues; antioxidant; PLA(2); H+/K+-ATPase; DERIVATIVES; POTENT;

D O I：

10.1134/S1068162015040020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of novel piperazine analogues bearing quinolin-8-yloxy-butan-1-ones/pyridin-2-yloxyethanones were synthesized by a simple and convenient approach based on various substituted piperazine incorporating quinoline and pyridine moieties. The analogues were evaluated for in vitro antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferrous ion radical scavenging activities and anti-inflammatory activity by inhibition of Vipera russelli venom (PLA(2)) and gastric K+/H+-ATPase activities. Most of the title compounds exhibited promising activity. Best antioxidant and PLA(2)-inhibiting activities were found for piperazine analogues with phenyl and nitro phenyl groups, whereas methoxy group on phenyl piperazine indicated selectivity for the H+/K+-ATPase.

引用

页码：554 / 561

页数：8

共 25 条

[1] Phospholipase A2, reactive oxygen species, and lipid peroxidation in CNS pathologies [J].

Adibhatla, Rao Muralikrishna ;

Hatcher, J. F. .

BMB REPORTS, 2008, 41 (08) :560-567

[2] Synthesis and antimicrobial activity of succinimido(2-aryl-4-oxo-3{[( quinolin-8-yloxy)acetyl]amino}-1,3-thiazolidin-5-yl)acetates [J].

Ahmed, Maqbool ;

Sharma, Ranjana ;

Nagda, Devendra P. ;

Jat, Jawahar L. ;

Talesara, Ganpat L. .

ARKIVOC, 2006, :66-75

[3] Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents [J].

Bandgar, Babasaheb P. ;

Patil, Sachin A. ;

Gacche, Rajesh N. ;

Korbad, Balaji L. ;

Hote, Balwant S. ;

Kinkar, Santosh N. ;

Jalde, Shivkumar S. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (02) :730-733

[4] An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression [J].

Becker, Oren M. ;

Dhanoa, Dale S. ;

Marantz, Yael ;

Chen, Dongli ;

Shacham, Sharon ;

Cheruku, Srinivasa ;

Heifetz, Alexander ;

Mohanty, Pradyumna ;

Fichman, Merav ;

Sharadendu, Anurag ;

Nudelman, Raphael ;

Kauffman, Michael ;

Noiman, Silvia .

JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (11) :3116-3135

[5] The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology [J].

Bedard, Karen ;

Krause, Karl-Heinz .

PHYSIOLOGICAL REVIEWS, 2007, 87 (01) :245-313

[6] CHROMATOGRAPHY OF RATTLESNAKE VENOM - A SEPARATION OF 3 PHOSPHODIESTERASES [J].

BOMAN, HG ;

KALETTA, U .

BIOCHIMICA ET BIOPHYSICA ACTA, 1957, 24 (03) :619-631

[7] The synthesis of L-carvone and limonene derivatives with increased antiproliferative effect and activation of ERK pathway in prostate cancer cells [J].

Chen, Jiaojiao ;

Lu, Min ;

Jing, Yongkui ;

Dong, Jinhua .

BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (19) :6539-6547

[8]

Ebrahim zadeh M.A., 2009, PHARMACOLOGY, V1, P1318

[9]

Fiske CH, 1925, J BIOL CHEM, V66, P375

[10]

Foye WO., 1995, PRINCIPLES MED CHEM, VFourth

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