EFFECTS OF 4-NONYLPHENOL ON THE IMMUNE SYSTEM OF RAINBOW TROUT (Oncorhynchus mykiss)

被引：0

作者：

Hebert, Nancy ^{[3
]}

Gagne, Francois ^{[1
]}

Cyr, Daniel ^{[3
]}

Pellerin, Jocelyne ^{[2
]}

Blaise, Christian

Fournier, Michel ^{[3
]}

机构：

[1] Environm Canada, Aquat Ecosyst Protect Res Div, Montreal, PQ H2Y 2E7, Canada

[2] ISMER, Rimouski, PQ G5L 3A1, Canada

[3] INRS Inst Armand Frappier, Pointe Claire, PQ H9R 1G6, Canada

来源：

FRESENIUS ENVIRONMENTAL BULLETIN | 2009年 / 18卷 / 5A期

关键词：

nonylphenol; immune system; rainbow trout; phagocytosis; macrophages; NCC; lymphocytes; CYTOTOXIC-CELL ACTIVITY; ST-LAWRENCE-RIVER; IN-VITRO; ESTROGENIC CHEMICALS; ATLANTIC SALMON; NONYLPHENOL; RESPONSES; EFFLUENT; VIVO; EXPOSURE;

D O I：

暂无

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Alkylphenol polyethoxylates are widely used as surfactants and find their way in urban wastewaters. Nonylphenol (NP) is a degradation product of these surfactants and contaminates also the aquatic biota. NP is clearly recognized as an estrogen but research focusing on the impacts of the immune system in fish is scarce. Our study therefore sought to investigate the effects of NP in juvenile rainbow trout (Oncorhynchus mykiss) on the immune system at the level of phagocytosis, lymphocyte B and T proliferation, as well as natural cytotoxic cell (NCC) activity. After 54 days of exposure to NP, trout showed a significant decrease of active phagocytic activity. NCC activity was significantly enhanced at 54 days when compared to controls. A moderate decrease in [H-3]-thymidine DNA incorporation was observed for T and B lymphocyte. These results suggest that NP can affect the immune system in juvenile rainbow trout at environmental levels thought to be safe for aquatic species.

引用

页码：757 / 761

页数：5

共 31 条

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