Clustering of the group III metabotropic glutamate receptor 4a at parallel fiber synaptic terminals in the rat cerebellar molecular layer

被引：29

作者：

Mateos, JM

Elezgarai, I

Benítez, R

Osorio, A

Bilbao, A

Azkue, JJ

Kuhn, R

Knöpfel, T

Grandes, P ^{[1
]}

机构：

[1] Univ Basque Country, Fac Med & Dent, Dept Neurosci, Bilbao 69948080, Spain

[2] Novartis Pharma Inc, Nervous Syst, CH-4002 Basel, Switzerland

[3] RIKEN, Brain Sci Inst, Lab Neuronal Circuit Dynam, Wako, Saitama 3510198, Japan

来源：

NEUROSCIENCE RESEARCH | 1999年 / 35卷 / 01期

关键词：

excitatory neurotransmission; cerebellum; G-proteins; immunogold; pre-embedding immunocytochemistry; electron microscopy;

D O I：

10.1016/S0168-0102(99)00066-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We report in this study with a pre-embedding immunogold method, the clustering of the group III metabotropic glutamate receptor 4a (mGluR4a) along the presynaptic membrane of parallel fiber synaptic terminals in the cerebellar molecular layer. The mGluR4a clusters were homogeneously distributed and interspaced by about 60 nm. These results suggest a particular arrangement of mGluR4a which might help to a rapid and effective activation of this receptor by glutamate. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：71 / 74

页数：4

共 26 条

[1] HIGH-RESOLUTION IMMUNOGOLD LOCALIZATION OF AMPA TYPE GLUTAMATE-RECEPTOR SUBUNITS AT SYNAPTIC AND NONSYNAPTIC SITES IN RAT HIPPOCAMPUS [J].