A practical guide to evaluating cardiovascular, renal, and pulmonary function in mice

被引：88
作者：
Lorenz, JN [1 ]
机构：
[1] Univ Cincinnati, Dept Cellular & Mol Physiol, Cincinnati, OH 45267 USA
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | 2002年 / 282卷 / 06期
关键词：
phenotype; methods; surgery; heart; lung; kidney;
D O I：
10.1152/ajpregu.00759.2001
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The development and widespread use of genetically altered mice to study the role of various proteins in biological control systems have led to a renewed interest in methodologies and approaches for evaluating physiological phenotypes. As a result, cross-disciplinary approaches have become essential for fully realizing the potential of these new and powerful animal models. The combination of classical physiological approaches and modern innovative technology has given rise to an impressive arsenal for evaluating the functional results of genetic manipulation in the mouse. This review attempts to summarize some of the techniques currently being used for measuring cardiovascular, renal, and pulmonary variables in the intact mouse, with specific attention to practical considerations useful for their successful implementation.
引用
收藏
页码：R1565 / R1582
页数：18
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