Variability of monthly nitrogen multiple-breath washout during one year in children with cystic fibrosis

被引：26
作者：
Green, Kent [1 ,2 ]
Kongstad, Thomas [1 ,2 ]
Skov, Marianne [1 ]
Buchvald, Frederik [1 ]
Rosthoj, Susanne [3 ]
Marott, Jacob Louis [4 ]
Gustafsson, Per [5 ]
Pressler, Tacjana [1 ]
Nielsen, Kim Gjerum [1 ]
机构：
[1] Rigshosp, Copenhagen Univ Hosp, Dept Paediat & Adolescent Med, CF Ctr Copenhagen,Paediat Pulm Serv, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
[2] Rigshosp, Copenhagen Univ Hosp, Res Unit Womens & Childrens Hlth, Tagensvej 20, DK-2100 Copenhagen, Denmark
[3] Univ Copenhagen, Dept Publ Hlth, Sect Biostat, Oster Farimagsgade 5,Entrance B,2 Floor, DK-1014 Copenhagen, Denmark
[4] Univ Copenhagen, Frederiksberg Hosp, Copenhagen City Heart Study, Nordre Fasanvej 57, DK-2000 Frederiksberg, Denmark
[5] Cent Hosp Skovde, Dept Paediat, Lovangsvagen, S-54185 Skovde, Sweden
来源：
JOURNAL OF CYSTIC FIBROSIS | 2018年 / 17卷 / 02期
关键词：
Cystic fibrosis; Paediatrics; Lung function; Nitrogen multiple-breath washout; Lung clearance index; LCI; LUNG CLEARANCE INDEX; INERT-GAS WASHOUT; VENTILATION INHOMOGENEITY; CLINIMETRIC PROPERTIES; DISEASE; SPIROMETRY; ADULTS; TESTS; CF; PHYSIOTHERAPY;
D O I：
10.1016/j.jcf.2017.11.007
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Background: Knowledge of between-session variability of nitrogen multiple-breath washout (N2MBW) indices is crucial when designing longitudinal interventional studies and in disease monitoring using N2MBW as end-point. Such information is currently sparse. Methods: Monthly triplets of N2MBW were prospectively obtained from 14 children with CF during one year. Linear mixed models were used to analyze variability. Our aim was to assess between-session variability of N2MBW indices from repeated measurements and compare LCI derived from different software packages currently in use (TestPoint vs. Spiroware). Results: Baseline LCI (median; range) was 9.37 (6.82; 12.08). Between-session differences in LCI measurements were up to 25%. Intra Class Correlation-Coefficient was 0.82. There was no systematic difference between LCI measurements derived from the two software packages (p = 0.18); however, variability was significantly higher using Spiroware. Conclusions: We report between-session variability of LCI using N2MBW in school-age children and adolescents with CF. LCI changes exceeding 25% may be considered clinically relevant. TestPoint and Spiroware can be used interchangeably in longitudinal studies. (C) 2017 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：242 / 248
页数：7
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