Prognostic value of preoperative diabetes mellitus in patients with non-functional pancreatic neuroendocrine neoplasms

被引：4

作者：

Tan, Qingquan ^{[1
]}

Wang, Xing ^{[1
]}

Chen, Chen ^{[2
]}

Liu, Xubao ^{[1
]}

Chen, Yonghua ^{[1
,3
]}

Tan, Chunlu ^{[1
,3
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Pancreat Surg, Chengdu, Sichuan, Peoples R China

[2] First Peoples Hosp Chengdu, Dept Radiol, Chengdu, Sichuan, Peoples R China

[3] Sichuan Univ, West China Hosp, Dept Pancreat Surg, 37 Guo Xue Alley, Chengdu 610041, Sichuan, Peoples R China

来源：

AMERICAN JOURNAL OF SURGERY | 2022年 / 224卷 / 04期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Pancreatic neuroendocrine neoplasms; Prognosis; Diabetes mellitus; New-onset diabetes; Impaired fasting glucose; POPULATION-BASED ANALYSIS; RISK-FACTORS; CANCER; TUMORS; SURVIVAL; GLUCOSE;

D O I：

10.1016/j.amjsurg.2022.05.026

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: The main aim of this study was to investigate the prevalence and prognostic value of preoperative diabetes mellitus (DM) in patients with non-functional pancreatic neuroendocrine neoplasms (NF-PNENs). Methods: Data were retrospectively collected from 190 patients with NF-PNENs from January 2009 to December 2019 in a single center. Results: The prevalence of longstanding DM, new-onset DM and impaired fasting glucose (IFG) was 11.6% (22/ 190), 8.4% (16/190), and 25.8% (49/190), respectively. Regression analysis showed that tumor size, tumor grade and lymph node metastasis were risk factors for new-onset DM and IFG. Multivariate survival analysis demonstrated preoperative new-onset DM (hazard ratio [HR], 4.33; P = 0.009) and IFG (HR, 4.53; P = 0.027) as independent predictors of poor recurrence-free survival (RFS) in patients with NF-PNENs. Conclusion: Preoperative new-onset DM and IFG are associated with aggressive tumor behavior and poor RFS in patients with NF-PNENs.

引用

页码：1162 / 1167

页数：6

共 31 条

[1] Long-term All-Cause Mortality in Cancer Patients With Preexisting Diabetes Mellitus A Systematic Review and Meta-analysis [J].

Barone, Bethany B. ;

Yeh, Hsin-Chieh ;

Snyder, Claire F. ;

Peairs, Kimberly S. ;

Stein, Kelly B. ;

Derr, Rachel L. ;

Wolff, Antonio C. ;

Brancati, Frederick L. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 300 (23) :2754-2764

[2] Risk Factors for Sporadic Pancreatic Neuroendocrine Tumors: A Case-Control Study [J].

Ben, Qiwen ;

Zhong, Jie ;

Fei, Jian ;

Chen, Haitao ;

Yv, Lifen ;

Tan, Jihong ;

Yuan, Yaozong .

SCIENTIFIC REPORTS, 2016, 6

[3] Diabetes mellitus and risk of pancreatic cancer: A meta-analysis of cohort studies [J].

Ben, Qiwen ;

Xu, Maojin ;

Ning, Xiaoyan ;

Liu, Jun ;

Hong, Shangyou ;

Huang, Wen ;

Zhang, Huagao ;

Li, Zhaoshen .

EUROPEAN JOURNAL OF CANCER, 2011, 47 (13) :1928-1937

[4] Risk Factors for Sporadic Pancreatic Endocrine Tumors: A Case-Control Study of Prospectively Evaluated Patients [J].

Capurso, Gabriele ;

Falconi, Massimo ;

Panzuto, Francesco ;

Rinzivillo, Maria ;

Boninsegna, Letizia ;

Bettini, Rossella ;

Corleto, Vito ;

Borgia, Piero ;

Pederzoli, Paolo ;

Scarpa, Aldo ;

Delle Fave, Gianfranco .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2009, 104 (12) :3034-3041

[5] Preoperative Diabetes Mellitus and Long-Term Survival After Resection of Pancreatic Adenocarcinoma [J].

Chu, Carrie K. ;

Mazo, Ashley E. ;

Goodman, Michael ;

Egnatashvili, Vasili ;

Sarmiento, Juan M. ;

Staley, Charles A. ;

Galloway, John R. ;

Adsay, N. Volkan ;

Jacobs, Sol ;

Kooby, David A. .

ANNALS OF SURGICAL ONCOLOGY, 2010, 17 (02) :502-513

[6] Trends in the Incidence, Prevalence, and Survival Outcomes in Patients With Neuroendocrine Tumors in the United States [J].

Dasari, Arvind ;

Shen, Chan ;

Halperin, Daniel ;

Zhao, Bo ;

Zhou, Shouhao ;

Xu, Ying ;

Shih, Tina ;

Yao, James C. .

JAMA ONCOLOGY, 2017, 3 (10) :1335-1342

[7] The Postoperative Occurrence or Worsening of Diabetes Mellitus May Increase the Risk of Recurrence in Resected Pancreatic Neuroendocrine Tumors [J].

de Mestier, Louis ;

Vedie, Anne-Laure ;

Faron, Matthieu ;

Cros, Jerome ;

Rebours, Vinciane ;

Hentic, Olivia ;

Do Cao, Christine ;

Bardet, Pascal ;

Levy, Philippe ;

Sauvanet, Alain ;

Ruszniewski, Philippe ;

Hammel, Pascal .

NEUROENDOCRINOLOGY, 2020, 110 (11-12) :967-976

[8] ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors [J].

Falconi, M. ;

Eriksson, B. ;

Kaltsas, G. ;

Bartsch, D. K. ;

Capdevila, J. ;

Caplin, M. ;

Kos-Kudla, B. ;

Kwekkeboom, D. ;

Rindi, G. ;

Kloeppel, G. ;

Reed, N. ;

Kianmanesh, R. ;

Jensen, R. T. .

NEUROENDOCRINOLOGY, 2016, 103 (02) :153-171

[9] Diabetes Is Associated With the Metastasis of Pancreatic Neuroendocrine Tumors [J].

Fan, Zhiyao ;

Gong, Yitao ;

Huang, Qiuyi ;

Yang, Chao ;

Cheng, He ;

Jin, Kaizhou ;

Fan, Kun ;

Ni, Quanxing ;

Yu, Xianjun ;

Luo, Guopei ;

Liu, Chen .

PANCREAS, 2020, 49 (06) :751-756

[10] Predicting Aggressive Behavior in Nonfunctional Pancreatic Neuroendocrine Tumors With Emphasis on Tumor Size Significance and Survival Trends: A Population-Based Analysis of 1787 Patients [J].

Fathi, Amir H. ;

Romanyshyn, Jonathan ;

Barati, Mehdi ;

Choudhury, Uzair ;

Chen, Allen ;

Sosa, Julie Ann .

AMERICAN SURGEON, 2020, 86 (05) :458-466

← 1 2 3 4 →