Low-dose computed tomography screening for lung cancer: results of the first screening round

被引：22

作者：

Horeweg, Nanda ^{[1
,2
]}

Nackaerts, Kristiaan ^{[3
]}

Oudkerk, Matthijs ^{[4
,5
]}

de Koning, Harry J. ^{[1
]}

机构：

[1] Erasmus Univ, Med Ctr, Dept Publ Hlth, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus Univ, Med Ctr, Dept Pulmonol, NL-3000 CA Rotterdam, Netherlands

[3] Univ Hosp Gasthuisberg, Dept Pulm Med, B-3000 Louvain, Belgium

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Radiol, NL-9713 GZ Groningen, Netherlands

[5] Univ Groningen, Univ Med Ctr Groningen, Ctr Med Imaging North East Netherlands, NL-9713 GZ Groningen, Netherlands

来源：

JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH | 2013年 / 2卷 / 05期

关键词：

early detection of cancer; histology; lung neoplasms; neoplasm staging; predictive value of tests; tomography; x-ray computed tomography; TRIAL; CT; MANAGEMENT;

D O I：

10.2217/cer.13.57

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Evaluation of: National Lung Screening Trial Research Team, Church TR, Black WC, Aberle DR et al. Results of initial low-dose computed tomographic screening for lung cancer. N. Engl. J. Med. 368, 1980-1991 (2013). In 2011, the US NLST trial demonstrated that mortality from lung cancer can be reduced by using low-dose computed tomography (LDCT) screening rather than chest x-ray (CXR) screening. This paper from the US NLST research team focuses on the results of the initial round of LDCT for lung cancer. A total of 53,439 participants were included and randomly assigned to LDCT screening (n = 26,715) or CXR screening (n = 26,724). In total, 27.3% of the participants in the LDCT group and 9.2% in the CXR group had a positive screening result. As a result, 3.8% (LDCT group) and 5.7% (CXR group) of these subjects were diagnosed with lung cancer. The sensitivity (93.8%) and specificity (73.4%) for lung cancer were higher for LDCT compared with CXR screening; 73.5 and 91.3%, respectively.

引用

页码：433 / 436

页数：4

共 16 条

[11] Annual or biennial CT screening versus observation in heavy smokers: 5-year results of the MILD trial [J].

Pastorino, Ugo ;

Rossi, Marta ;

Rosato, Valentina ;

Marchiano, Alfonso ;

Sverzellati, Nicola ;

Morosi, Carlo ;

Fabbri, Alessandra ;

Galeone, Carlotta ;

Negri, Eva ;

Sozzi, Gabriella ;

Pelosi, Giuseppe ;

La Vecchia, Carlo .

EUROPEAN JOURNAL OF CANCER PREVENTION, 2012, 21 (03) :308-315

[12] CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT [J].

Saghir, Zaigham ;

Dirksen, Asger ;

Ashraf, Haseem ;

Bach, Karen Skjoldstrup ;

Brodersen, John ;

Clementsen, Paul Frost ;

Dossing, Martin ;

Hansen, Hanne ;

Kofoed, Klaus Fuglsang ;

Larsen, Klaus Richter ;

Mortensen, Jann ;

Rasmussen, Jakob Fraes ;

Seersholm, Niels ;

Skov, Birgit Guldhammer ;

Thorsen, Hanne ;

Tonnesen, Philip ;

Pedersen, Jesper Holst .

THORAX, 2012, 67 (04) :296-301

[13] Cancer statistics, 2013 [J].

Siegel, Rebecca ;

Naishadham, Deepa ;

Jemal, Ahmedin .

CA-A CANCER JOURNAL FOR CLINICIANS, 2013, 63 (01) :11-30

[14] Management of Lung Nodules Detected by Volume CT Scanning [J].

van Klaveren, Rob J. ;

Oudkerk, Matthijs ;

Prokop, Mathias ;

Scholten, Ernst T. ;

Nackaerts, Kristiaan ;

Vernhout, Rene ;

van Iersel, Carola A. ;

van den Bergh, Karien A. M. ;

van't Westeinde, Susan ;

van der Aalst, Carlijn ;

Thunnissen, Erik ;

Xu, Dong Ming ;

Wang, Ying ;

Zhao, Yingru ;

Gietema, Hester A. ;

de Hoop, Bart-Jan ;

Groen, Harry J. M. ;

de Bock, Geertruida H. ;

van Ooijen, Peter ;

Weenink, Carla ;

Verschakelen, Johny ;

Lammers, Jan-Willem J. ;

Timens, Wim ;

Willebrand, Dik ;

Vink, Aryan ;

Mali, Willem ;

de Koning, Harry J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (23) :2221-2229

[15] American Cancer Society Lung Cancer Screening Guidelines [J].

Wender, Richard ;

Fontham, Elizabeth T. H. ;

Barrera, Ermilo, Jr. ;

Colditz, Graham A. ;

Church, Timothy R. ;

Ettinger, David S. ;

Etzioni, Ruth ;

Flowers, Christopher R. ;

Gazelle, G. Scott ;

Kelsey, Douglas K. ;

LaMonte, Samuel J. ;

Michaelson, James S. ;

Oeffinger, Kevin C. ;

Shih, Ya-Chen Tina ;

Sullivan, Daniel C. ;

Travis, William ;

Walter, Louise ;

Wolf, Andrew M. D. ;

Brawley, Otis W. ;

Smith, Robert A. .

CA-A CANCER JOURNAL FOR CLINICIANS, 2013, 63 (02) :107-117

[16] Nodule management protocol of the NELSON randomised lung cancer screening trial [J].

Xu, Dong Ming ;

Gietema, Hester ;

de Koning, Harry ;

Vernhout, Rene ;

Nackaerts, Kristiaan ;

Prokop, Mathias ;

Weenink, Carla ;

Lammers, Jan-Willem ;

Groen, Harry ;

Oudkerk, Matthijs ;

van Klaveren, Rob .

LUNG CANCER, 2006, 54 (02) :177-184

← 1 2 →