Low-dose computed tomography screening for lung cancer: results of the first screening round

被引：22

作者：

Horeweg, Nanda ^{[1
,2
]}

Nackaerts, Kristiaan ^{[3
]}

Oudkerk, Matthijs ^{[4
,5
]}

de Koning, Harry J. ^{[1
]}

机构：

[1] Erasmus Univ, Med Ctr, Dept Publ Hlth, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus Univ, Med Ctr, Dept Pulmonol, NL-3000 CA Rotterdam, Netherlands

[3] Univ Hosp Gasthuisberg, Dept Pulm Med, B-3000 Louvain, Belgium

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Radiol, NL-9713 GZ Groningen, Netherlands

[5] Univ Groningen, Univ Med Ctr Groningen, Ctr Med Imaging North East Netherlands, NL-9713 GZ Groningen, Netherlands

来源：

JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH | 2013年 / 2卷 / 05期

关键词：

early detection of cancer; histology; lung neoplasms; neoplasm staging; predictive value of tests; tomography; x-ray computed tomography; TRIAL; CT; MANAGEMENT;

D O I：

10.2217/cer.13.57

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Evaluation of: National Lung Screening Trial Research Team, Church TR, Black WC, Aberle DR et al. Results of initial low-dose computed tomographic screening for lung cancer. N. Engl. J. Med. 368, 1980-1991 (2013). In 2011, the US NLST trial demonstrated that mortality from lung cancer can be reduced by using low-dose computed tomography (LDCT) screening rather than chest x-ray (CXR) screening. This paper from the US NLST research team focuses on the results of the initial round of LDCT for lung cancer. A total of 53,439 participants were included and randomly assigned to LDCT screening (n = 26,715) or CXR screening (n = 26,724). In total, 27.3% of the participants in the LDCT group and 9.2% in the CXR group had a positive screening result. As a result, 3.8% (LDCT group) and 5.7% (CXR group) of these subjects were diagnosed with lung cancer. The sensitivity (93.8%) and specificity (73.4%) for lung cancer were higher for LDCT compared with CXR screening; 73.5 and 91.3%, respectively.

引用

页码：433 / 436

页数：4

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