Clinical relevance of adverse intracerebral artery remodeling in patients with HIV

被引：1

作者：

Montecucco, Fabrizio ^{[1
,2
]}

Carbone, Federico ^{[2
]}

机构：

[1] Univ Genoa, IRCCS Azienda Osped Univ San Martino, IST Ist Nazl Ric Canc, Dept Internal Med,Sch Med, Genoa, Italy

[2] Univ Geneva, Dept Med Specialties, Fdn Med Res, Div Cardiol, CH-1211 Geneva 4, Switzerland

来源：

NEUROLOGY | 2015年 / 85卷 / 13期

关键词：

RISK; INTERRUPTION; STROKE; MEN;

D O I：

10.1212/WNL.0000000000001983

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Although associated with some alterations of lipid metabolism and development of lipodystrophy, combination antiretroviral therapy (cART) abrogated infections in patients with HIV and improved the quality and expectancy of life.(1) This therapeutic success has allowed the recognition of an association between HIV infection and cardiovascular diseases.(2,3) Long-lived patients with HIV exhibited a marked acceleration of atherosclerosis with an increased risk of acute ischemic events.(3,4) Thus, long-term cardiovascular comorbidities might weaken the relative immune defense benefits induced by cART. It remains unclear if cART directly increases cardiovascular risk or if virus-derived compounds could be responsible for atherogenesis. For instance, recent evidence from clinical trials suggested that viral replication rebound during interruption of cART may provoke a rapid increase of serum levels of cardiovascular risk biomarkers as well as of clinical cardiovascular events.(2,5) Recent results from the Veterans Aging Cohort Study-Virtual Cohort demonstrated an increased risk of cerebral disease, including ischemic stroke, in HIV-positive patients.(6) On the other hand, the Framingham Risk Score for Stroke prediction systematically underestimates the long-term risk of stroke in HIV-positive men, suggesting that many unknown factors might influence the pathophysiology in the cerebral circulation in HIV.(7</SUP)

引用

页码：1098 / 1099

页数：2

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