Case History: Discovery of Ixabepilone (IXEMPRA™), a First-in-Class Epothilone Analog for Treatment of Metastatic Breast Cancer

被引：10

作者：

Borzilleri, Robert M. ^{[1
]}

Vite, Gregory D. ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, R&D, Princeton, NJ 08543 USA

来源：

ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 44 | 2009年 / 44卷

关键词：

MICROTUBULE-STABILIZING AGENTS; BIOSYNTHETIC GENE-CLUSTER; SORANGIUM-CELLULOSUM; B ANALOG; CLINICAL DEVELOPMENT; HETEROLOGOUS EXPRESSION; TUBULIN POLYMERIZATION; BIOLOGICAL-ACTIVITY; ANTITUMOR-ACTIVITY; SOLID TUMORS;

D O I：

10.1016/S0065-7743(09)04415-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：301 / 322

页数：22

共 72 条

[51] Synthesis of epothilones A and B in solid and solution phase [J].

Nicolaou, KC ;

Winssinger, N ;

Pastor, J ;

Ninkovic, S ;

Sarabia, F ;

He, Y ;

Vourloumis, D ;

Yang, Z ;

Li, T ;

Giannakakou, P ;

Hamel, E .

NATURE, 1997, 387 (6630) :268-272

[52] Total synthesis of epothilone A: The macrolactonization approach [J].

Nicolaou, KC ;

Sarabia, F ;

Ninkovic, S ;

Yang, Z .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1997, 36 (05) :525-527

[53] Recent developments in the chemistry, biology and medicine of the epothilones [J].

Nicolaou, KC ;

Ritzén, A ;

Namoto, K .

CHEMICAL COMMUNICATIONS, 2001, (17) :1523-1535

[54] In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models [J].

Peterson, JK ;

Tucker, C ;

Favours, E ;

Cheshire, PJ ;

Creech, J ;

Billups, CA ;

Smykla, R ;

Lee, FYF ;

Houghton, PJ .

CLINICAL CANCER RESEARCH, 2005, 11 (19) :6950-6958

[55] SAR and pH stability of cyano-substituted epothilones [J].

Regueiro-Ren, A ;

Leavitt, K ;

Kim, SH ;

Höfle, G ;

Kiffe, M ;

Gougoutas, JZ ;

DiMarco, JD ;

Lee, FYF ;

Fairchild, CR ;

Long, BH ;

Vite, GD .

ORGANIC LETTERS, 2002, 4 (22) :3815-3818

[56] Synthesis and biological activity of novel epothilone aziridines [J].

Regueiro-Ren, A ;

Borzilleri, RM ;

Zheng, XP ;

Kim, SH ;

Johnson, JA ;

Fairchild, CR ;

Lee, FYF ;

Long, BH ;

Vite, GD .

ORGANIC LETTERS, 2001, 3 (17) :2693-2696

[57] PROMOTION OF MICROTUBULE ASSEMBLY INVITRO BY TAXOL [J].

SCHIFF, PB ;

FANT, J ;

HORWITZ, SB .

NATURE, 1979, 277 (5698) :665-667

[58] Total synthesis of (-)-epothilone A [J].

Schinzer, D ;

Limberg, A ;

Bauer, A ;

Bohm, OM ;

Cordes, M .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1997, 36 (05) :523-524

[59] Complete genome sequence of the myxobacterium Sorangium cellulosum [J].

Schneiker, Susanne ;

Perlova, Olena ;

Kaiser, Olaf ;

Gerth, Klaus ;

Alici, Aysel ;

Altmeyer, Matthias O. ;

Bartels, Daniela ;

Bekel, Thomas ;

Beyer, Stefan ;

Bode, Edna ;

Bode, Helge B. ;

Bolten, Christoph J. ;

Choudhuri, Jomuna V. ;

Doss, Sabrina ;

Elnakady, Yasser A. ;

Frank, Bettina ;

Gaigalat, Lars ;

Goesmann, Alexander ;

Groeger, Carolin ;

Gross, Frank ;

Jelsbak, Lars ;

Jelsbak, Lotte ;

Kalinowski, Joern ;

Kegler, Carsten ;

Knauber, Tina ;

Konietzny, Sebastian ;

Kopp, Maren ;

Krause, Lutz ;

Krug, Daniel ;

Linke, Bukhard ;

Mahmud, Taifo ;

Martinez-Arias, Rosa ;

McHardy, Alice C. ;

Merai, Michelle ;

Meyer, Folker ;

Mormann, Sascha ;

Munoz-Dorado, Jose ;

Perez, Juana ;

Pradella, Silke ;

Rachid, Shwan ;

Raddatz, Guenter ;

Rosenau, Frank ;

Rueckert, Christian ;

Sasse, Florenz ;

Scharfe, Maren ;

Schuster, Stephan C. ;

Suen, Garret ;

Treuner-Lange, Anke ;

Velicer, Gregory J. ;

Vorhoelter, Frank-Joerg .

NATURE BIOTECHNOLOGY, 2007, 25 (11) :1281-1289

[60]

Schnizer D, 2000, CHEMBIOCHEM, V1, P67, DOI 10.1002/1439-7633(20000703)1:1<67::AID-CBIC67>3.0.CO

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