Neurological considerations: Autism and Parkinson's disease

被引：22

作者：

Hollander, Eric ^{[1
]}

Wang, A. Ting ^{[1
]}

Braun, Ashley ^{[1
]}

Marsh, Laura ^{[2
,3
]}

机构：

[1] Albert Einstein Coll Med, Univ Hosp, Montefiore Med Ctr, Dept Psychiat, Bronx, NY 10467 USA

[2] Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

来源：

PSYCHIATRY RESEARCH | 2009年 / 170卷 / 01期

关键词：

Obsessive-compulsive spectrum; Obsessive-compulsive disorder; Autism; Parkinson's disease; Impulse Control Disorders; OBSESSIVE-COMPULSIVE DISORDER; SEROTONIN TRANSPORTER GENE; IMPULSE CONTROL DISORDERS; REPETITIVE BEHAVIORS; DOUBLE-BLIND; ASSOCIATION ANALYSIS; SPECTRUM DISORDERS; TOURETTES-SYNDROME; ANXIETY DISORDERS; BASAL GANGLIA;

D O I：

10.1016/j.psychres.2008.07.014

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Within the spectrum of disorders that manifest obsessive-compulsive (OC) features lies a sub-cluster of neurological conditions. Autism and Parkinson's disease (PD) are examples of two such neurological disorders that seem quite dissimilar on the surface. Yet, both conditions can include repetitive behaviors of a compulsive-impulsive nature. Furthermore, while autism and PD differ in other associated symptom domains that shape the course of each disorder, both disorders share some phenomenology in the core domain of repetitive behaviors and involve basal ganglia and frontal lobe dysfunction, similar to OC disorder (OCD). Accordingly, examination of the similarities and differences between autism and PD may provide insight into the pathophysiology and treatment of OC spectrum disorders. The current review focuses on the phenomenology. comorbidity, course of illness, family history, brain circuitry, and treatment of autism and PD, as they relate to OCD and OC spectrum disturbances. (c) 2008 Elsevier Ireland Ltd. All rights reserved

引用

页码：43 / 51

页数：9

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