Synthesis of 6-iodo/bromo-3-amino-2-methylquinazolin-4-(3H)-ones by direct halogenation and their Schiff base derivatives

被引：23
作者：
Sayyed, Mudassar A. [1 ]
Mokle, Shyam S. [1 ]
Vibhute, Yeshwant B. [1 ]
机构：
[1] Yeshwant Mahavidyalaya, PG Dept Chem, Nanded 431602, MS, India
来源：
ARKIVOC | 2006年
关键词：
6-iodo; bromo 3-amino-2-methylquinazolin-4 (3H) -ones; Schiff bases; antibacterial activity;
D O I：
10.3998/ark.5550190.0007.b22
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Treatment of 3-amino-2-methylquinazolin-4(3H)-one with iodine monochloride or bromine in acetic acid affords the corresponding 6-iodo / bromo 3-amino-2-methylquinazolin-4 (3H)-ones in high yields. The notable advantages of this protocol are, no need of catalyst, mild conditions, simple operation and short reaction times with high yields. New potentially active Schiff bases are prepared by condensing these 6-iodo / bromo 3-amino-2-methylquinazolin-4 (3H)-ones with different substituted aryl aldehydes. The bioactivity of the synthesized Schiff bases is studied.
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页码：221 / 226
页数：6
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