Biology of Langerhans cells and Langerhans cell histiocytosis

被引：51

作者：

Bechan, G. I. ^{[1
]}

Egeler, R. M.

Arceci, R. J.

机构：

[1] Leiden Univ, Med Ctr, Dept Pediat Immunol, NL-2300 RC Leiden, Netherlands

[2] Johns Hopkins Med Inst, Div Pediat Oncol, Baltimore, MD 21231 USA

来源：

INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 254 | 2006年 / 254卷

关键词：

Langerhans cell; Langerhans cell histiocytosis cell; Langerhans cell histiocytosis; cytokines; bystander cells;

D O I：

10.1016/S0074-7696(06)54001-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Langerhans cells (LC) are epidermal dendritic cells (DC). They play an important role in the initiation of immune responses through antigen uptake, processing, and presentation to T cells. Langerhans cell histiocytosis (LCH) is a rare disease in which accumulation of cells with LC characteristics (LCH cells) occur. LCH lesions are further characterized by the presence of other cell types, such as T cells, multinucleated giant cells (MGC), macrophages (M Phi), eosinophils, stromal cells, and natural killer cells (NK cells). Much has been learned about the pathophysiology of LCH by studying properties of these different cells and their interaction with each other through cytokines/chemokines. In this review we discuss the properties and interactions of the different cells involved in LCH pathophysiology with the hope of better understanding this enigmatic disorder.

引用

页码：1 / 43

页数：43

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