Emerging roles of PPARs in inflammation and immunity

被引:791
作者
Daynes, RA
Jones, DC
机构
[1] Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT 84132 USA
[2] Vet Affairs Med Ctr, Ctr Geriatr Res Educ & Clin, Salt Lake City, UT 84112 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nri912
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Lipids and lipid metabolism have well-documented regulatory effects on inflammatory processes. Recent work has highlighted the role of the peroxisome proliferator-activated receptors (PPARs) - a subset of the nuclear-hormone-receptor superfamily that are activated by various lipid species - in regulating inflammatory responses. Here, we describe how the PPARs, through their interactions with transcription factors and other cell-signalling systems, have important regulatory roles in innate and adaptive immunity.
引用
收藏
页码:748 / 759
页数:12
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