Synthesis of potential fungicides based on N-(3-furanyl)pyrrolecarboxamides and N-(3-furanyl)pyrazolecarboxamides

被引：11

作者：

Kolodziejczyk, Krzysztof ^{[1
]}

Roiban, Gheorghe D. ^{[2
]}

Schnuerch, Michael ^{[1
]}

Mihovilovic, Marko D. ^{[1
]}

Stanetty, Peter ^{[1
]}

机构：

[1] Vienna Univ Technol, Inst Appl Synthet Chem, A-1060 Vienna, Austria

[2] Univ Babes Bolyai, Fac Chem & Chem Engn, Cluj Napoca 400028, Romania

来源：

MONATSHEFTE FUR CHEMIE | 2009年 / 140卷 / 11期

关键词：

ortho Lithiation; Fungicides; Organometallic compounds; Heterocycles; Suzuki reaction; DIRECTED METALATION REACTIONS; DERIVATIVES; ACIDS;

D O I：

10.1007/s00706-009-0187-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient synthesis of novel N-(3-furanyl)pyrrolecarboxamides and N-(3-furanyl)pyrazolecarboxamides is presented starting from furan-3-carboxylic acid. Two complementary strategies to 2-aryl-3-furanamines with directed ortho lithiation, functionalization of the 2-position, and subsequent cross-coupling reaction as key steps were developed. Acylation of these intermediates with appropriate acid chlorides led finally to the target compounds.

引用

页码：1349 / 1359

页数：11

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