RecQ helicases in DNA repair and cancer targets

被引：17

作者：

Newman, Joseph A. ^{[1
]}

Gileadi, Opher ^{[1
]}

机构：

[1] Univ Oxford, Struct Genom Consortium, Oxford OX3 7DQ, England

来源：

GUARDIANS OF THE GENOME: DNA DAMAGE AND REPAIR | 2020年 / 64卷 / 05期

关键词：

BLOOMS-SYNDROME HELICASE; WERNER-SYNDROME PROTEIN; WINGED-HELIX DOMAIN; RNA-POLYMERASE-II; HRDC DOMAIN; REPLICATION FORK; SMALL-MOLECULE; FUNCTIONAL INTERACTION; STRAND-SEPARATION; CRYSTAL-STRUCTURE;

D O I：

10.1042/EBC20200012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Helicases are enzymes that use the energy derived from ATP hydrolysis to catalyze the unwinding of DNA or RNA. The RecQ family of helicases is conserved through evolution from prokaryotes to higher eukaryotes and plays important roles in various DNA repair pathways, contributing to the maintenance of genome integrity. Despite their roles as general tumor suppressors, there is now considerable interest in exploiting RecQ helicases as synthetic lethal targets for the development of new cancer therapeutics. In this review, we summarize the latest developments in the structural and mechanistic study of RecQ helicases and discuss their roles in various DNA repair pathways. Finally, we consider the potential to exploit RecQ helicases as therapeutic targets and review the recent progress towards the development of small molecules targeting RecQ helicases as cancer therapeutics.

引用

页码：819 / 830

页数：12

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