Synthesis and antitumor activity evaluation of novel substituted 5H-benzo[i][1,3,4]thiadiazolo[3,2-a]quinazoline-6,7-diones

被引：15

作者：

Wu, Liqiang ^{[1
]}

Zhang, Chong ^{[1
]}

机构：

[1] Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 34期

关键词：

BETA-LAPACHONE; NAPHTHOQUINONES; CYTOTOXICITY; DERIVATIVES; ANTIFUNGAL;

D O I：

10.1039/c6ra03323g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel substituted 5H-benzo[i][1,3,4]thiadiazolo[3,2-a]quinazoline-6,7-diones, designed via a molecular hybridization approach, were synthesized in very good yields using one-pot condensation of 2-hydroxy-1,4-naphthoquinone, aldehydes, and 5-substituted-2-amino-1,3,4-thiadiazole. The antitumor activities of all the synthesized compounds were assessed on two different human cancer cell lines (HCT116 and HepG2), and the results showed that most of the new compounds showed good to potent cytotoxic activities.

引用

页码：28555 / 28562

页数：8

共 50 条

[21] Regioselective synthesis of new 5-methyl-5H-pyrimido[4′,5′:4,5][1,3]thiazino [3,2-a]perimidines [J].

Firoozi, Neda ;

Bakavoli, Mehdi ;

Eshghi, Hossein ;

Ramezanian, Navid .

JOURNAL OF SULFUR CHEMISTRY, 2017, 38 (05) :488-495

[22] An efficient green synthesis of 5H-spiro[benzo[4,5] imidazo[1,2-c] quinazoline-6,3′-indolin]-2′-ones catalyzed by iodine in ionic liquids [J].

Zhang, Mei-Mei ;

Wang, Yue ;

Liu, Jian-Quan ;

Wang, Xiang-Shan .

HETEROCYCLIC COMMUNICATIONS, 2017, 23 (05) :385-388

[23] Synthesis and Antitumor Activity of 5,6-2H-[1,2,4]-Triazolo [3,4-b][1,3,4]thiadiazine Derivatives [J].

Zheng, Yuguo ;

Xue, Wei ;

Guo, Qingqing ;

Lu, Ping ;

Wang, Zhenchao ;

Yuan, Kai .

CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2011, 31 (06) :912-916

[24] Synthesis and Antimicrobial Activity of Novel 1,3,4-Oxadiazolyl-quinazolin-4(3H)ones [J].

Patel, Navin B. ;

Patel, Jaymin C. .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2010, 47 (04) :923-931

[25] Design, Synthesis and Biological Evaluation of Novel 6-Benzyl-2-benzylidene-2H-thiazolo[3,2-b][1,2,4]triazine-3,7-diones as Acetylcholinesterase Inhibitors [J].

Liu, Si-jie ;

Zhao, Xing ;

Zhang, Zhi-hui ;

Wang, Juan ;

He, Jing-yu .

CHEMISTRYSELECT, 2022, 7 (10)

[26] Synthesis and antitumor activity of novel 1-substituted phenyl 3-(2-oxo-1,3,4-oxadiazol-5-yl) β-carbolines and their Mannich bases [J].

Savariz, Franciele Cristina ;

Foglio, Mary Ann ;

Goes Ruiz, Ana Lucia T. ;

da Costa, Willian Ferreira ;

Silva, Marina de Magalhaes ;

Caldas Santos, Josue Carinhanha ;

Figueiredo, Isis Martins ;

Meyer, Emerson ;

de Carvalho, Joao Ernesto ;

Sarragiotto, Maria Helena .

BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (24) :6867-6875

[27] Synthesis, characterization, and urease inhibition of 5-substituted-8-methyl-2H-pyrido[1,2-a]pyrimidine-2,4(3H)-diones [J].

Rauf, Abdul ;

Liaqat, Sumaira ;

Qureshi, Ashfaq M. ;

Yaqub, Muhammad ;

Rehman, Aziz U. ;

Hassan, Mahmood U. ;

Chohan, Zahid H. ;

Nasim, Faiz U. H. ;

Ben Hadda, T. .

MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (01) :60-74

[28] Crystal structure of 1-amino-3-(4-chlorophenyl)-2cyano-3H-benzo[4,5]thiazolo[3,2-a]pyridine-4- carboxamide [J].

Metwally, Nadia H. ;

Elgemeie, Galal H. ;

Al-Latif, El-Shimaa S. M. Abd ;

Jones, Peter G. .

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2025, 81 :279-+

[29] Synthesis and antitumor activity evaluation of 2-arylisoquinoline-1,3(2H,4H)-diones in vitro and in vivo [J].

Kang, Bo-Rui ;

Wang, Juan ;

Li, Huan ;

Li, Yan ;

Mei, Qi-Bing ;

Zhang, San-Qi .

MEDICINAL CHEMISTRY RESEARCH, 2014, 23 (03) :1340-1349

[30] Synthesis, evaluation of antimicrobial activity, and molecular modeling of novel 2-((4-(2H-benzo[d] [1,2,3] triazol-2-yl)piperidin-1-yl)methyl)-5-substituted phenyl-1,3,4-oxadiazoles [J].

Vankadari, Srinivas Rao ;

Mandala, Devender ;

Pochampalli, Jalapathi ;

Tigulla, Parthasarathy ;

Valeru, Anil ;

Thampu, Rajakomuraiah .

MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (12) :5912-5919

← 1 2 3 4 5 →