A site- and stereoselective intermolecular alkene-alkyne coupling process

被引：48
作者：
Reichard, Holly A. [1 ]
Micalizio, Glenn C. [1 ]
机构：
[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 09期
关键词：
alkenes; alkynes; C-C coupling; metallacycles; titanium;
D O I：
10.1002/anie.200603515
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Ti-ght union: A highly regio- and stereo-selective bimolecular coupling reaction is described for the union of substituted, unactivated olefins and internal alkynes (see scheme). The titanium-mediated coupling reaction proceeds with C-C bond formation occurring distal to a pendent hydroxy group. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：1440 / 1443
页数：4
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