Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma

被引：18

作者：

Morinishi, Tatsuya ^{[1
]}

Tokuhara, Yasunori ^{[2
]}

Ohsaki, Hiroyuki ^{[3
]}

Ibuki, Emi ^{[4
]}

Kadota, Kyuichi ^{[4
]}

Hirakawa, Eiichiro ^{[1
]}

机构：

[1] Kagawa Prefectural Univ Hlth Sci, Dept Med Technol, Lab Pathol, Takamatsu, Kagawa 7610123, Japan

[2] Ehime Prefectural Univ Hlth Sci, Dept Med Technol, Tobe, Ehime 7912101, Japan

[3] Kobe Univ, Grad Sch Hlth Sci, Dept Med Biophys, Lab Pathol, Kobe, Hyogo 6540142, Japan

[4] Kagawa Univ, Fac Med, Univ Hosp, Dept Diagnost Pathol, Miki, Kagawa 7610793, Japan

来源：

PPAR RESEARCH | 2019年 / 2019卷

关键词：

NF-KAPPA-B; PPAR-ALPHA; DIFFERENTIAL EXPRESSION; BETA-CATENIN; COLON-CANCER; FENOFIBRATE; GAMMA; CELLS; APOPTOSIS; BCL-2;

D O I：

10.1155/2019/7486727

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Peroxisome proliferator-activated receptor alpha (PPAR-alpha) belongs to the PPAR family and plays a critical role in inhibiting cell proliferation and tumorigenesis in various tumors. However, the role of PPAR-alpha in colorectal tumorigenesis is unclear. In the present study, we found that fenofibrate, a PPAR-alpha agonist, significantly inhibited cell proliferation and induced apoptosis in colorectal carcinoma cells. In addition, PPAR-alpha was expressed in the nucleus of colorectal carcinoma cells, and the expression of nuclear PPAR-alpha increased in colorectal carcinoma tissue compared with that of normal epithelium tissue (P<0.01). The correlation between the expression of nuclear PPAR-alpha and clinicopathological factors was evaluated in human colorectal carcinoma tissues, and the nuclear expression of PPAR-alpha was significantly higher in well-to-moderately differentiated adenocarcinoma than in mucinous adenocarcinoma (P<0.05). These findings indicate that activation of PPAR-alpha may be involved in anticancer effects in colorectal carcinomas, and nuclear expression of PPAR-alpha may be a therapeutic target for colorectal adenocarcinoma treatment.

引用

页数：9

共 43 条

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