Nutritional Challenges in Duchenne Muscular Dystrophy

被引:48
作者
Salera, Simona [1 ]
Menni, Francesca [1 ]
Moggio, Maurizio [2 ]
Guez, Sophie [1 ]
Sciacco, Monica [2 ]
Esposito, Susanna [3 ]
机构
[1] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Pathophysiol & Transplantat, Pediat Highly Intens Care Unit, I-20122 Milan, Italy
[2] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Neurosci, Neuromuscular & Rare Dis Unit, I-20122 Milan, Italy
[3] Univ Perugia, Pediat Clin, I-06129 Perugia, Italy
关键词
dysphagia; hyponutrition; neuromuscular disease; nutrition; osteoporosis; overnutrition; RESTING ENERGY-EXPENDITURE; BODY-COMPOSITION; FEEDING PROBLEMS; NUTRIENT INTAKE; BONE-DENSITY; CHILDREN; DYSPHAGIA; ATROPHY; DISORDERS; PATTERNS;
D O I
10.3390/nu9060594
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Neuromuscular diseases (NMDs) represent a heterogeneous group of acquired or inherited conditions. Nutritional complications are frequent in NMDs, but they are sometimes underestimated. With the prolongation of survival in patients with NMDs, there are several nutritional aspects that are important to consider, including the deleterious effects of overnutrition on glucose metabolism, mobility, and respiratory and cardiologic functions; the impact of hyponutrition on muscle and ventilatory function; constipation and other gastrointestinal complications; chewing/swallowing difficulties with an increased risk of aspiration that predisposes to infectious diseases and respiratory complications; as well as osteoporosis with an associated increased risk of fractures. The aim of this review is to provide a comprehensive analysis of the nutritional aspects and complications that can start in children with Duchenne muscular dystrophy (DMD) and increase with ageing. These aspects should be considered in the transition from paediatric clinics to adult services. It is shown that appropriate nutritional care can help to improve the quality of life of DMD patients, and a multidisciplinary team is needed to support nutrition challenges in DMD patients. However, studies on the prevalence of overnutrition and undernutrition, gastrointestinal complications, infectious diseases, dysphagia, and reduced bone mass in the different types of NMDs are needed, and appropriate percentiles of weight, height, body mass index, and body composition appear to be extremely important to improve the management of patients with NMD.
引用
收藏
页数:10
相关论文
共 30 条
[1]   Dysphagia in Duchenne muscular dystrophy assessed by validated questionnaire [J].
Archer, Sally K. ;
Garrod, Rachel ;
Hart, Nicholas ;
Miller, Simon .
INTERNATIONAL JOURNAL OF LANGUAGE & COMMUNICATION DISORDERS, 2013, 48 (02) :240-246
[2]   Low bone density and bone metabolism alterations in Duchenne muscular dystrophy: response to calcium and vitamin D treatment [J].
Bianchi, M. L. ;
Morandi, L. ;
Andreucci, E. ;
Vai, S. ;
Frasunkiewicz, J. ;
Cottafava, R. .
OSTEOPOROSIS INTERNATIONAL, 2011, 22 (02) :529-539
[3]  
Bianchi Maria Luisa, 2011, Neuromuscul Disord, V21, P298, DOI 10.1016/j.nmd.2011.02.006
[4]   Evolution of gastric electrical features and gastric emptying in children with Duchenne and Becker muscular dystrophy [J].
Borrelli, O ;
Salvia, G ;
Mancini, V ;
Santoro, L ;
Tagliente, F ;
Romeo, EF ;
Cucchiara, S .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2005, 100 (03) :695-702
[5]   Diagnosis and management of Duchenne muscular dystrophy, part 2: implementation of multidisciplinary care [J].
Bushby, Katharine ;
Finkel, Richard ;
Birnkrant, David J. ;
Case, Laura E. ;
Clemens, Paula R. ;
Cripe, Linda ;
Kaul, Ajay ;
Kinnett, Kathi ;
McDonald, Craig ;
Pandya, Shree ;
Poysky, James ;
Shapiro, Frederic ;
Tomezsko, Jean ;
Constantin, Carolyn .
LANCET NEUROLOGY, 2010, 9 (02) :177-189
[6]   A review of nutrition in Duchenne muscular dystrophy [J].
Davidson, Z. E. ;
Truby, H. .
JOURNAL OF HUMAN NUTRITION AND DIETETICS, 2009, 22 (05) :383-393
[7]   Nutrition Considerations in Duchenne Muscular Dystrophy [J].
Davis, Jillian ;
Samuels, Emily ;
Mullins, Lucille .
NUTRITION IN CLINICAL PRACTICE, 2015, 30 (04) :511-521
[8]  
DiVito D.M.T., 2012, TOP CLIN NUTR, V27, P11
[9]   Position of the Academy of Nutrition and Dietetics: Total Diet Approach to Healthy Eating [J].
Freeland-Graves, Jeanne H. ;
Nitzke, Susan .
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS, 2013, 113 (02) :307-317
[10]   A NEW CHART FOR WEIGHT CONTROL IN DUCHENNE MUSCULAR-DYSTROPHY [J].
GRIFFITHS, RD ;
EDWARDS, RHT .
ARCHIVES OF DISEASE IN CHILDHOOD, 1988, 63 (10) :1256-1258