WNK Kinase Signaling in Ion Homeostasis and Human Disease

被引：175

作者：

Shekarabi, Masoud ^{[1
]}

Zhang, Jinwei ^{[2
,3
]}

Khanna, Arjun R. ^{[4
,5
]}

Ellison, David H. ^{[6
,7
]}

Delpire, Eric ^{[8
]}

Kahle, Kristopher T. ^{[2
,9
,10
]}

机构：

[1] Temple Univ, Lewis Katz Sch Med, Dept Neurosci, Philadelphia, PA 19140 USA

[2] Yale Sch Med, Dept Neurosurg, Ctr Mendelian Genom, New Haven, CT 06477 USA

[3] Univ Dundee, Prot Phosphorylat & Ubiquitylat Unit, MRC, Coll Life Sci, Dundee DD1 5EH, Scotland

[4] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA

[5] Harvard Med Sch, Dept Neurosurg, Boston, MA 02115 USA

[6] Oregon Hlth & Sci Univ, Dept Med, Div Nephrol & Hypertens, Portland, OR 97239 USA

[7] VA Portland Hlth Care Syst, Portland, OR 97239 USA

[8] Vanderbilt Univ, Sch Med, Dept Anesthesiol, Nashville, TN 37232 USA

[9] Yale Sch Med, Centers Mendelian Genom, Dept Pediat, New Haven, CT 06477 USA

[10] Yale Sch Med, Centers Mendelian Genom, Dept Cellular & Mol Physiol, New Haven, CT 06477 USA

来源：

CELL METABOLISM | 2017年 / 25卷 / 02期

关键词：

K-CL COTRANSPORTER; FAMILIAL HYPERKALEMIC HYPERTENSION; KELCH-LIKE; 3; PSEUDOHYPOALDOSTERONISM TYPE-II; CONDITIONAL MOUSE MODEL; ALANINE-RICH KINASE; CELL-VOLUME; BLOOD-PRESSURE; ANGIOTENSIN-II; INTESTINAL INFLAMMATION;

D O I：

10.1016/j.cmet.2017.01.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl- cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.

引用

页码：285 / 299

页数：15

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