WNK Kinase Signaling in Ion Homeostasis and Human Disease

被引：163
作者：
Shekarabi, Masoud [1 ]
Zhang, Jinwei [2 ,3 ]
Khanna, Arjun R. [4 ,5 ]
Ellison, David H. [6 ,7 ]
Delpire, Eric [8 ]
Kahle, Kristopher T. [2 ,9 ,10 ]
机构：
[1] Temple Univ, Lewis Katz Sch Med, Dept Neurosci, Philadelphia, PA 19140 USA
[2] Yale Sch Med, Dept Neurosurg, Ctr Mendelian Genom, New Haven, CT 06477 USA
[3] Univ Dundee, Prot Phosphorylat & Ubiquitylat Unit, MRC, Coll Life Sci, Dundee DD1 5EH, Scotland
[4] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA
[5] Harvard Med Sch, Dept Neurosurg, Boston, MA 02115 USA
[6] Oregon Hlth & Sci Univ, Dept Med, Div Nephrol & Hypertens, Portland, OR 97239 USA
[7] VA Portland Hlth Care Syst, Portland, OR 97239 USA
[8] Vanderbilt Univ, Sch Med, Dept Anesthesiol, Nashville, TN 37232 USA
[9] Yale Sch Med, Centers Mendelian Genom, Dept Pediat, New Haven, CT 06477 USA
[10] Yale Sch Med, Centers Mendelian Genom, Dept Cellular & Mol Physiol, New Haven, CT 06477 USA
来源：
CELL METABOLISM | 2017年 / 25卷 / 02期
关键词：
K-CL COTRANSPORTER; FAMILIAL HYPERKALEMIC HYPERTENSION; KELCH-LIKE; 3; PSEUDOHYPOALDOSTERONISM TYPE-II; CONDITIONAL MOUSE MODEL; ALANINE-RICH KINASE; CELL-VOLUME; BLOOD-PRESSURE; ANGIOTENSIN-II; INTESTINAL INFLAMMATION;
D O I：
10.1016/j.cmet.2017.01.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl- cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.
引用
收藏
页码：285 / 299
页数：15
相关论文
共 146 条
  • [1] Regulation of K-Cl cotransport: from function to genes
    Adragna, NC
    Di Fulvio, M
    Lauf, PK
    [J]. JOURNAL OF MEMBRANE BIOLOGY, 2004, 201 (03) : 109 - 137
  • [2] The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters
    Alessi, Dario R.
    Zhang, Jinwei
    Khanna, Arjun
    Hochdoerfer, Thomas
    Shang, Yuze
    Kahle, Kristopher T.
    [J]. SCIENCE SIGNALING, 2014, 7 (334)
  • [3] Inhibition of Na+-K+-2Cl- Cotransporter isoform 1 Accelerates Temozolomide-mediated Apoptosis in Glioblastoma Cancer Cells
    Algharabli, Jehad
    Kintner, Douglas B.
    Wang, Qiwei
    Begum, Gulnaz
    Clark, Paul A.
    Yang, Sung-Sen
    Lin, Shih-Hua
    Kahle, Kristopher T.
    Kuo, John S.
    Sun, Dandan
    [J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2012, 30 (01) : 33 - 48
  • [4] VANADATE AND FLUORIDE EFFECTS ON NA+-K+-CL- COTRANSPORT IN SQUID GIANT-AXON
    ALTAMIRANO, AA
    BREITWIESER, GE
    RUSSELL, JM
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 254 (04): : C582 - C586
  • [5] WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells
    Anselmo, Anthony N.
    Earnest, Svetlana
    Chen, Wei
    Juang, Yu-Chi
    Kim, Sung Chan
    Zhao, Yingming
    Cobb, Melanie H.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (29) : 10883 - 10888
  • [6] Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke
    Begum, Gulnaz
    Yuan, Hui
    Kahle, Kristopher T.
    Li, Liaoliao
    Wang, Shaoxia
    Shi, Yejie
    Shmukler, Boris E.
    Yang, Sung-Sen
    Lin, Shih-Hua
    Alper, Seth L.
    Sun, Dandan
    [J]. STROKE, 2015, 46 (07) : 1956 - 1965
  • [7] Excitatory actions of GABA during development: The nature of the nurture
    Ben-Ari, Y
    [J]. NATURE REVIEWS NEUROSCIENCE, 2002, 3 (09) : 728 - 739
  • [8] Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold
    Boettger, T
    Rust, MB
    Maier, H
    Seidenbecher, T
    Schweizer, M
    Keating, DJ
    Faulhaber, J
    Ehmke, H
    Pfeffer, C
    Scheel, O
    Lemcke, B
    Horst, J
    Leuwer, R
    Pape, HC
    Völkl, H
    Hübner, CA
    Jentsch, TJ
    [J]. EMBO JOURNAL, 2003, 22 (20) : 5422 - 5434
  • [9] Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury
    Boulenguez, Pascale
    Liabeuf, Sylvie
    Bos, Remi
    Bras, Helene
    Jean-Xavier, Celine
    Brocard, Cecile
    Stil, Aurelie
    Darbon, Pascal
    Cattaert, Daniel
    Delpire, Eric
    Marsala, Martin
    Vinay, Laurent
    [J]. NATURE MEDICINE, 2010, 16 (03) : 302 - U97
  • [10] Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities
    Boyden, Lynn M.
    Choi, Murim
    Choate, Keith A.
    Nelson-Williams, Carol J.
    Farhi, Anita
    Toka, Hakan R.
    Tikhonova, Irina R.
    Bjornson, Robert
    Mane, Shrikant M.
    Colussi, Giacomo
    Lebel, Marcel
    Gordon, Richard D.
    Semmekrot, Ben A.
    Poujol, Alain
    Valimaki, Matti J.
    De Ferrari, Maria E.
    Sanjad, Sami A.
    Gutkin, Michael
    Karet, Fiona E.
    Tucci, Joseph R.
    Stockigt, Jim R.
    Keppler-Noreuil, Kim M.
    Porter, Craig C.
    Anand, Sudhir K.
    Whiteford, Margo L.
    Davis, Ira D.
    Dewar, Stephanie B.
    Bettinelli, Alberto
    Fadrowski, Jeffrey J.
    Belsha, Craig W.
    Hunley, Tracy E.
    Nelson, Raoul D.
    Trachtman, Howard
    Cole, Trevor R. P.
    Pinsk, Maury
    Bockenhauer, Detlef
    Shenoy, Mohan
    Vaidyanathan, Priya
    Foreman, John W.
    Rasoulpour, Majid
    Thameem, Farook
    Al-Shahrouri, Hania Z.
    Radhakrishnan, Jai
    Gharavi, Ali G.
    Goilav, Beatrice
    Lifton, Richard P.
    [J]. NATURE, 2012, 482 (7383) : 98 - U126
12345678910