G2A and LPC: Regulatory functions in immunity

被引：113
作者：
Kabarowski, Janusz H. [1 ]
机构：
[1] Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA
来源：
PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2009年 / 89卷 / 3-4期
关键词：
G2A receptor; Lysophosphatidylcholine; Immunity; Inflammation; Chronic inflammatory disease; Autoimmunity; PROTEIN-COUPLED-RECEPTOR; SYSTEMIC-LUPUS-ERYTHEMATOSUS; HIGH-DENSITY-LIPOPROTEIN; SECRETORY PHOSPHOLIPASE A(2); APOPTOTIC CELLS; 9-HYDROXYOCTADECADIENOIC ACID; ANTIINFLAMMATORY PROPERTIES; CHOLESTEROL TRANSPORT; RHEUMATOID-ARTHRITIS; EXPERIMENTAL SEPSIS;
D O I：
10.1016/j.prostaglandins.2009.04.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The G2A receptor was originally identified by virtue of its transcriptional induction in routine B lymphoid cells in response to oncogenic transformation and treatment with Various DNA-damaging agents. While preliminary characterization of cellular responses to G2A overexpression in fibroblastic cell lines suggested that this receptor may negatively regulate cell growth under conditions Of proliferative and genotoxic stress, subsequent studies driven by the discovery of lysophosphatidylcholine (LPC) as a regulator of G2A signaling in immunoregulatory cells point to an important role for this receptor in innate and adaptive immunity. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：73 / 81
页数：9
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