Why Build Whole-Cell Models?

被引：49
作者：
Carrera, Javier [1 ]
Covert, Markus W. [1 ]
机构：
[1] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
来源：
TRENDS IN CELL BIOLOGY | 2015年 / 25卷 / 12期
关键词：
ESCHERICHIA-COLI; NETWORKS;
D O I：
10.1016/j.tcb.2015.09.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Our ability to build computational models that account for all known gene functions in a cell has increased dramatically. But why build whole-cell models, and how can they best be used? In this forum, we enumerate several areas in which whole-cell modeling can significantly impact research and technology.
引用
收藏
页码：719 / 722
页数：4
相关论文
共 15 条
  • [11] Noise Contributions in an Inducible Genetic Switch: A Whole-Cell Simulation Study
    Roberts, Elijah
    Magis, Andrew
    Ortiz, Julio O.
    Baumeister, Wolfgang
    Luthey-Schulten, Zaida
    [J]. PLOS COMPUTATIONAL BIOLOGY, 2011, 7 (03)
  • [12] Sanghvi JC, 2013, NAT METHODS, V10, P1192, DOI [10.1038/NMETH.2724, 10.1038/nmeth.2724]
  • [13] Whole-cell simulation: a grand challenge of the 21st century
    Tomita, M
    [J]. TRENDS IN BIOTECHNOLOGY, 2001, 19 (06) : 205 - 210
  • [14] MyMpn: a database for the systems biology model organism Mycoplasma pneumoniae
    Wodke, Judith A. H.
    Alibes, Andreu
    Cozzuto, Luca
    Hermoso, Antonio
    Yus, Eva
    Lluch-Senar, Maria
    Serrano, Luis
    Roma, Guglielmo
    [J]. NUCLEIC ACIDS RESEARCH, 2015, 43 (D1) : D618 - D623
  • [15] Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima
    Zhang, Ying
    Thiele, Ines
    Weekes, Dana
    Li, Zhanwen
    Jaroszewski, Lukasz
    Ginalski, Krzysztof
    Deacon, Ashley M.
    Wooley, John
    Lesley, Scott A.
    Wilson, Ian A.
    Palsson, Bernhard
    Osterman, Andrei
    Godzik, Adam
    [J]. SCIENCE, 2009, 325 (5947) : 1544 - 1549
12