Why Build Whole-Cell Models?

被引:49
作者
Carrera, Javier [1 ]
Covert, Markus W. [1 ]
机构
[1] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
关键词
ESCHERICHIA-COLI; NETWORKS;
D O I
10.1016/j.tcb.2015.09.004
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Our ability to build computational models that account for all known gene functions in a cell has increased dramatically. But why build whole-cell models, and how can they best be used? In this forum, we enumerate several areas in which whole-cell modeling can significantly impact research and technology.
引用
收藏
页码:719 / 722
页数:4
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  • [1] CellNet: Network Biology Applied to Stem Cell Engineering
    Cahan, Patrick
    Li, Hu
    Morris, Samantha A.
    da Rocha, Edroaldo Lummertz
    Daley, George Q.
    Collins, James J.
    [J]. CELL, 2014, 158 (04) : 903 - 915
  • [2] An integrative, multi-scale, genome-wide model reveals the phenotypic landscape of Escherichia coli
    Carrera, Javier
    Estrela, Raissa
    Luo, Jing
    Rai, Navneet
    Tsoukalas, Athanasios
    Tagkopoulos, Ilias
    [J]. MOLECULAR SYSTEMS BIOLOGY, 2014, 10 (07)
  • [3] Computational design of genomic transcriptional networks with adaptation to varying environments
    Carrera, Javier
    Elena, Santiago F.
    Jaramillo, Alfonso
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (38) : 15277 - 15282
  • [4] Probabilistic integrative modeling of genome-scale metabolic and regulatory networks in Escherichia coli and Mycobacterium tuberculosis
    Chandrasekaran, Sriram
    Price, Nathan D.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (41) : 17845 - 17850
  • [5] CORRECTION
    DOMACH, MM
    [J]. BIOTECHNOLOGY AND BIOENGINEERING, 1984, 26 (09) : 1140 - 1140
  • [6] Predicting network functions with nested patterns
    Ganter, Mathias
    Kaltenbach, Hans-Michael
    Stelling, Joerg
    [J]. NATURE COMMUNICATIONS, 2014, 5 : 3006
  • [7] Metabolic Engineering of Escherichia coli for the Production of Polylactic Acid and Its Copolymers
    Jung, Yu Kyung
    Kim, Tae Yong
    Park, Si Jae
    Lee, Sang Yup
    [J]. BIOTECHNOLOGY AND BIOENGINEERING, 2010, 105 (01) : 161 - 171
  • [8] A Whole-Cell Computational Model Predicts Phenotype from Genotype
    Karr, Jonathan R.
    Sanghvi, Jayodita C.
    Macklin, Derek N.
    Gutschow, Miriam V.
    Jacobs, Jared M.
    Bolival, Benjamin
    Assad-Garcia, Nacyra, Jr.
    Glass, John I.
    Covert, Markus W.
    [J]. CELL, 2012, 150 (02) : 389 - 401
  • [9] Towards a whole-cell modeling approach for synthetic biology
    Purcell, Oliver
    Jain, Bonny
    Karr, Jonathan R.
    Covert, Markus W.
    Lu, Timothy K.
    [J]. CHAOS, 2013, 23 (02)
  • [10] Systems approach to refining genome annotation
    Reed, Jennifer L.
    Patel, Trina R.
    Chen, Keri H.
    Joyce, Andrew R.
    Applebee, Margaret K.
    Herring, Christopher D.
    Bui, Olivia T.
    Knight, Eric M.
    Fong, Stephen S.
    Palsson, Bernhard O.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (46) : 17480 - 17484