Why Build Whole-Cell Models?

被引：49

作者：

Carrera, Javier ^{[1
]}

Covert, Markus W. ^{[1
]}

机构：

[1] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

来源：

TRENDS IN CELL BIOLOGY | 2015年 / 25卷 / 12期

关键词：

ESCHERICHIA-COLI; NETWORKS;

D O I：

10.1016/j.tcb.2015.09.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Our ability to build computational models that account for all known gene functions in a cell has increased dramatically. But why build whole-cell models, and how can they best be used? In this forum, we enumerate several areas in which whole-cell modeling can significantly impact research and technology.

引用

页码：719 / 722

页数：4

共 15 条

[1] CellNet: Network Biology Applied to Stem Cell Engineering [J].

Cahan, Patrick ;

Li, Hu ;

Morris, Samantha A. ;

da Rocha, Edroaldo Lummertz ;

Daley, George Q. ;

Collins, James J. .

CELL, 2014, 158 (04) :903-915

[2] An integrative, multi-scale, genome-wide model reveals the phenotypic landscape of Escherichia coli [J].

Carrera, Javier ;

Estrela, Raissa ;

Luo, Jing ;

Rai, Navneet ;

Tsoukalas, Athanasios ;

Tagkopoulos, Ilias .

MOLECULAR SYSTEMS BIOLOGY, 2014, 10 (07)

[3] Computational design of genomic transcriptional networks with adaptation to varying environments [J].

Carrera, Javier ;

Elena, Santiago F. ;

Jaramillo, Alfonso .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (38) :15277-15282

[4] Probabilistic integrative modeling of genome-scale metabolic and regulatory networks in Escherichia coli and Mycobacterium tuberculosis [J].

Chandrasekaran, Sriram ;

Price, Nathan D. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (41) :17845-17850

[5]

DOMACH MM, 1984, BIOTECHNOL BIOENG, V26, P1140, DOI 10.1002/bit.260260925

[6] Predicting network functions with nested patterns [J].

Ganter, Mathias ;

Kaltenbach, Hans-Michael ;

Stelling, Joerg .

NATURE COMMUNICATIONS, 2014, 5 :3006

[7] Metabolic Engineering of Escherichia coli for the Production of Polylactic Acid and Its Copolymers [J].

Jung, Yu Kyung ;

Kim, Tae Yong ;

Park, Si Jae ;

Lee, Sang Yup .

BIOTECHNOLOGY AND BIOENGINEERING, 2010, 105 (01) :161-171

[8] A Whole-Cell Computational Model Predicts Phenotype from Genotype [J].

Karr, Jonathan R. ;

Sanghvi, Jayodita C. ;

Macklin, Derek N. ;

Gutschow, Miriam V. ;

Jacobs, Jared M. ;

Bolival, Benjamin ;

Assad-Garcia, Nacyra, Jr. ;

Glass, John I. ;

Covert, Markus W. .

CELL, 2012, 150 (02) :389-401

[9] Towards a whole-cell modeling approach for synthetic biology [J].

Purcell, Oliver ;

Jain, Bonny ;

Karr, Jonathan R. ;

Covert, Markus W. ;

Lu, Timothy K. .

CHAOS, 2013, 23 (02)

[10] Systems approach to refining genome annotation [J].

Reed, Jennifer L. ;

Patel, Trina R. ;

Chen, Keri H. ;

Joyce, Andrew R. ;

Applebee, Margaret K. ;

Herring, Christopher D. ;

Bui, Olivia T. ;

Knight, Eric M. ;

Fong, Stephen S. ;

Palsson, Bernhard O. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (46) :17480-17484

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