Overview of Colorectal Cancer Genetics

被引：7

作者：

Gryfe, Robert ^{[1
,2
]}

机构：

[1] Univ Toronto, Mt Sinai Hosp, Dept Surg, Toronto, ON M5G 1X5, Canada

[2] Univ Toronto, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2009年 / 18卷 / 04期

关键词：

Colorectal cancer genetics; Tumor suppressor genes; Oncogenes; Chromosomal instability; Microsatellite instability; CpG island methylation; ISLAND METHYLATOR PHENOTYPE; NONPOLYPOSIS COLON-CANCER; ABERRANT CRYPT FOCI; CAUSE CHROMOSOMAL INSTABILITY; TUMOR-SUPPRESSOR GENE; MICROSATELLITE INSTABILITY; ADENOMATOUS POLYPOSIS; GERMLINE MUTATIONS; JUVENILE POLYPOSIS; CELL-LINES;

D O I：

10.1016/j.soc.2009.08.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is a genetic disease in which the clonal accumulation of genetic alterations confers a cell with the malignant characteristics of uncontrolled growth, local invasiveness, and metastastic potential. Studies of colorectal cancer and its precursor lesion, the adenomatous polyp, have served as the cornerstone in advancing knowledge of cancer molecular genetics. The past 30 years have ushered in an era of revolutionary increases in understanding colorectal cancer genetics. In the future, it is hoped that the tremendous recent gains made in understanding colorectal cancer genetics will allow for significant, tailored chemoprevention and treatment of this common malignancy.

引用

页码：573 / +

页数：12

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