Malaria vaccine development: Lessons from the field

被引：6

作者：

Todryk, Stephen ^{[1
]}

Bejon, Philip ^{[2
]}

机构：

[1] Northumbria Univ, Sch Appl Sci, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England

[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Oxford OX3 9DU, England

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2009年 / 39卷 / 08期

关键词：

Immune responses; Malaria; Vaccination; FALCIPARUM CIRCUMSPOROZOITE PROTEIN; NATURALLY ACQUIRED-IMMUNITY; PLASMODIUM-FALCIPARUM; CLINICAL MALARIA; T-CELLS; ANTIBODY-RESPONSES; SURFACE-ANTIGENS; WESTERN KENYA; VIRUS ANKARA; PROTECTION;

D O I：

10.1002/eji.200939529

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Studies and trials in the field are key to the development of a vaccine for malaria. Our limited knowledge of naturally acquired immunity and of transmission dynamics and disease causation in the field imposes limitations on our ability to predict the efficacy of candidate vaccinations, and the eventual outcome on deploying an efficacious vaccine at a population level.

引用

页码：2007 / 2010

页数：4

共 40 条

[1] Efficacy of RTS,S/AS01E Vaccine against Malaria in Children 5 to 17 Months of Age [J].

Bejon, Philip ;

Lusingu, John ;

Olotu, Ally ;

Leach, Amanda ;

Lievens, Marc ;

Vekemans, Johan ;

Mshamu, Salum ;

Lang, Trudie ;

Gould, Jayne ;

Dubois, Marie-Claude ;

Demoitie, Marie-Ange ;

Stallaert, Jean-Francois ;

Vansadia, Preeti ;

Carter, Terrell ;

Njuguna, Patricia ;

Awuondo, Ken O. ;

Malabeja, Anangisye ;

Abdul, Omar ;

Gesase, Samwel ;

Mturi, Neema ;

Drakeley, Chris J. ;

Savarese, Barbara ;

Villafana, Tonya ;

Ballou, W. Ripley ;

Cohen, Joe ;

Riley, Eleanor M. ;

Lemnge, Martha M. ;

Marsh, Kevin ;

von Seidlein, Lorenz .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (24) :2521-2532

[2] A phase 2b randomised trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in Kenya [J].

Bejon, Philip ;

Mwacharo, Jedidah ;

Kai, Oscar ;

Mwangi, Tabitha ;

Milligan, Paul ;

Todryk, Stephen ;

Keating, Sheila ;

Lang, Trudie ;

Lowe, Brett ;

Gikonyo, Caroline ;

Molyneux, Catherine ;

Fegan, Greg ;

Gilbert, Sarah C. ;

Peshu, Norbert ;

Marsh, Kevin ;

Hill, Adrian V. S. .

PLOS CLINICAL TRIALS, 2006, 1 (06)

[3] Analysis of Immunity to Febrile Malaria in Children That Distinguishes Immunity from Lack of Exposure [J].

Bejon, Philip ;

Warimwe, George ;

Mackintosh, Claire L. ;

Mackinnon, Margaret J. ;

Kinyanjui, Sam M. ;

Musyoki, Jennifer N. ;

Bull, Peter C. ;

Marsh, Kevin .

INFECTION AND IMMUNITY, 2009, 77 (05) :1917-1923

[4] Safety and immunogenicty of RTS,S/AS02A candidate malaria vaccine in Gambian children [J].

Bojang, KA ;

Olodude, F ;

Pinder, M ;

Ofori-Anyinam, O ;

Vigneron, L ;

Fitzpatrick, S ;

Njie, F ;

Kassanga, A ;

Leach, A ;

Milman, J ;

Rabinovich, R ;

McAdam, KPWJ ;

Kester, KE ;

Heppner, DG ;

Cohen, JD ;

Tornieporth, N ;

Milligan, PJM .

VACCINE, 2005, 23 (32) :4148-4157

[5] The role of antibodies to Plasmodium falciparum-infected-erythrocyte surface antigens in naturally acquired immunity to malaria [J].

Bull, PC ;

Marsh, K .

TRENDS IN MICROBIOLOGY, 2002, 10 (02) :55-58

[6] Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria [J].

Bull, PC ;

Lowe, BS ;

Kortok, M ;

Molyneux, CS ;

Newbold, CI ;

Marsh, K .

NATURE MEDICINE, 1998, 4 (03) :358-360

[7] Plasmodium falciparum variant surface antigen expression patterns during malaria [J].

Bull, Peter C. ;

Berriman, Matthew ;

Kyes, Sue ;

Quail, Michael A. ;

Hall, Neil ;

Kortok, Moses M. ;

Marsh, Kevin ;

Newbold, Chris I. .

PLOS PATHOGENS, 2005, 1 (03) :202-213

[8]

CALLE JMC, 1992, J IMMUNOL, V149, P2695

[9] Human CD4+ T cells induced by synthetic peptide malaria vaccine are comparable to cells elicited by attenuated Plasmodium falciparum sporozoites [J].

Calvo-Calle, JM ;

Oliveira, GA ;

Nardin, EH .

JOURNAL OF IMMUNOLOGY, 2005, 175 (11) :7575-7585

[10] Loss of Population Levels of Immunity to Malaria as a Result of Exposure-Reducing Interventions: Consequences for Interpretation of Disease Trends [J].

Ghani, Azra C. ;

Sutherland, Colin J. ;

Riley, Eleanor M. ;

Drakeley, Chris J. ;

Griffin, Jamie T. ;

Gosling, Roly D. ;

Filipe, Joao A. N. .

PLOS ONE, 2009, 4 (02)

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