Recent advances in the field of caloric restriction mimetics and anti-aging molecules

被引：51

作者：

Martel, Jan ^{[1
,2
]}

Chang, Shih-Hsin ^{[1
,2
]}

Wu, Cheng-Yeu ^{[1
,2
,3
]}

Peng, Hsin-Hsin ^{[1
,2
,4
]}

Hwang, Tsong-Long ^{[5
,6
,7
,8
]}

Ko, Yun-Fei ^{[2
,9
,10
]}

Young, John D. ^{[10
]}

Ojcius, David M. ^{[1
,2
,11
]}

机构：

[1] Chang Gung Univ, Ctr Mol & Clin Immunol, Taoyuan, Taiwan

[2] Chang Gung Mem Hosp Linkou, Chang Gung Immunol Consortium, Taoyuan, Taiwan

[3] Chang Gung Univ, Res Ctr Bacterial Pathogenesis, Taoyuan, Taiwan

[4] Chang Gung Mem Hosp Linkou, Lab Anim Ctr, Taoyuan, Taiwan

[5] Chang Gung Univ, Grad Inst Nat Prod, Coll Med, Taoyuan, Taiwan

[6] Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med, Taoyuan, Taiwan

[7] Chang Gung Univ Sci & Technol, Grad Inst Hlth Ind Technol, Coll Human Ecol, Taoyuan, Taiwan

[8] Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan, Taiwan

[9] Ming Chi Univ Technol, Biochem Engn Res Ctr, New Taipei, Taiwan

[10] Chang Gung Biotechnol Corp, Taipei, Taiwan

[11] Univ Pacific, Arthur Dugoni Sch Dent, Dept Biomed Sci, San Francisco, CA USA

来源：

AGEING RESEARCH REVIEWS | 2021年 / 66卷

关键词：

Aging; Autophagy; Hormesis; Phytochemicals; Polysaccharides; EXTENDS LIFE-SPAN; NITRIC-OXIDE; HEALTH; RESVERATROL; GLUCOSAMINE; DIET; HORMESIS; PHYTOCHEMICALS; REGENERATION; TARGET;

D O I：

10.1016/j.arr.2020.101240

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Caloric restriction (CR) mimetics are molecules that produce beneficial effects on health and longevity in model organisms and humans, without the challenges of maintaining a CR diet. Conventional CR mimetics such as metformin, rapamycin and spermidine activate autophagy, leading to recycling of cellular components and improvement of physiological function. We review here novel CR mimetics and anti-aging compounds, such as 4,4'-dimethoxychalcone, fungal polysaccharides, inorganic nitrate, and trientine, highlighting their possible molecular targets and mechanisms of action. The activity of these compounds can be understood within the context of hormesis, a biphasic dose response that involves beneficial effects at low or moderate doses and toxic effects at high doses. The concept of hormesis has widespread implications for the identification of CR mimetics in experimental assays, testing in clinical trials, and use in healthy humans. We also discuss the promises and limitations of CR mimetics and anti-aging molecules for delaying aging and treating chronic diseases.

引用

页数：6