Pre-conception status, obstetric outcome and use of medications during pregnancy of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) in Japan: Multi-center retrospective descriptive study

被引：20

作者：

Tsuda, Sayaka ^{[1
]}

Sameshima, Azusa ^{[1
]}

Sekine, Michikazu ^{[2
]}

Kawaguchi, Haruna ^{[3
]}

Fujita, Daisuke ^{[4
]}

Makino, Shintaro ^{[5
]}

Morinobu, Akio ^{[6
]}

Murakawa, Yohko ^{[7
]}

Matsui, Kiyoshi ^{[8
]}

Sugiyama, Takao ^{[9
]}

Watanabe, Mamoru ^{[10
]}

Suzuki, Yasuo ^{[11
]}

Nagahori, Masakazu ^{[12
]}

Murashima, Atsuko ^{[13
]}

Atsumi, Tatsuya ^{[14
,15
]}

Oku, Kenji ^{[14
,15
]}

Mitsuda, Nobuaki ^{[3
]}

Takei, Syuji ^{[16
]}

Miyamae, Takako ^{[17
]}

Takahashi, Naoto ^{[18
]}

Nakajima, Ken ^{[19
]}

Saito, Shigeru ^{[1
]}

Age, Minist Hlth Labour Welfare Working Grp Guideline Treatment Rheumatoid Arthr

机构：

[1] Univ Toyama, Dept Obstet & Gynecol, Toyama, Japan

[2] Univ Toyama, Grad Sch Med & Pharmaceut Sci, Dept Epidemiol & Hlth Policy, Toyama, Japan

[3] Osaka Womens & Childrens Hospita, Dept Maternal Fetal Med, Osaka, Japan

[4] Osaka Med Coll, Dept Obstet & Gynecol, Osaka, Japan

[5] Juntendo Univ, Fac Med, Dept Obstet & Gynecol, Tokyo, Japan

[6] Kobe Univ, Grad Sch Med, Dept Internal Med, Div Rheumatol & Clin Immunol, Kobe, Hyogo, Japan

[7] Shimane Univ, Fac Med, Dept Rheumatol, Matsue, Shimane, Japan

[8] Hyogo Coll Med, Dept Internal Med, Div Rheumatol, Nishinomiya, Hyogo, Japan

[9] Natl Hosp Org Shimoshizu Natl Hosp, Dept Rheumatol, Yotuskaido City, Japan

[10] Tokyo Med & Dent Univ, Dept Gastroenterol & Hepatol, Tokyo, Japan

[11] Toho Univ, Sakura Med Ctr, Inflammatory Bowel Dis Ctr, Chiba, Japan

[12] Tokyo Med & Dent Univ, Hosp Med, Clin Res Ctr, Tokyo, Japan

[13] Natl Ctr Child Hlth & Dev, Ctr Maternal Fetal Neonatal & Reprod Med, Tokyo, Japan

[14] Hokkaido Univ, Grad Sch Med, Dept Rheumatol Endocrinol & Nephrol, Sapporo, Hokkaido, Japan

[15] Hokkaido Univ, Fac Med, Sapporo, Hokkaido, Japan

[16] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Pediat, Kagoshima, Japan

[17] Tokyo Womens Med Univ, Inst Rheumatol, Dept Pediat Rheumatol, Tokyo, Japan

[18] Univ Tokyo Hosp, Dept Pediat & Neonatal Intens Care, Tokyo, Japan

[19] Natl Hosp Org Sagamihara Natl Hosp, Dept Pharm, Sagamihara, Kanagawa, Japan

来源：

MODERN RHEUMATOLOGY | 2020年 / 30卷 / 05期

关键词：

Crohn's disease; pregnancy; rheumatoid arthritis; systemic lupus erythematosus; ulcerative colitis; REGULATORY T-CELLS; AUTOIMMUNE-DISEASES; WOMEN; FETAL; NEPHRITIS; MOTHERS; FLARE; RISK; RECOMMENDATIONS; CONTRACEPTION;

D O I：

10.1080/14397595.2019.1661592

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To describe the pre-conception status, pregnancy outcomes, and medication prevalence in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Crohn's disease (CD), and ulcerative colitis (UC). Methods: E-mail-based questionnaire survey for the Japan Maternal Fetal Intensive Care Unit Network hospitals inquiring prevalence and clinical features of SLE, RA, CD and UC complicated pregnancies for 2 years. Results: The number of SLE, RA, CD and UC among 69,810 deliveries was 184, 139, 27 and 178, respectively. Less than half of pregnancies were planned. Assisted reproductive technology (ART) pregnancy rates were higher in SLE, RA and UC than in the general population (11.4, 23.0 and 7.4 vs 5.1%, p < .001 each). Preterm delivery, preeclampsia, and fetal growth restriction (FGR) were more frequent in SLE than in the general population (39.4 vs. 5.6% p < .001, 15.0 vs. 6.0% p < .001, 12.9 vs 4.2% p < .001). Prevalence of preterm delivery in RA and UC (27.5 vs. 5.6% p < .001, 11.3 vs. 5.6% p < .05) and FGR in CD (28.6 vs. 4.2% p < .001) was also higher than that in the general population. Conclusion: SLE, RA, CD, and UC complicated pregnancies were at high risks of obstetric adverse outcome. High ART rates necessitate pre-conception counseling in SLE, RA, and UC pregnancies.

引用

页码：852 / 861

页数：10

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