Schwann cell plasticity-roles in tissue homeostasis, regeneration, and disease

被引:89
作者
Stierli, Salome [1 ]
Imperatore, Valerio [1 ]
Lloyd, Alison C. [1 ]
机构
[1] UCL, MRC LMCB, London WC1E 6BT, England
基金
英国医学研究理事会;
关键词
BOUNDARY CAP CELLS; CREST STEM-CELLS; PERIPHERAL-NERVE REGENERATION; NEURAL CREST; GLIAL-CELLS; MULTIPLE-SCLEROSIS; C-JUN; NEUROMUSCULAR-JUNCTION; PERINEURAL INVASION; SENSORY GANGLIA;
D O I
10.1002/glia.23643
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
How tissues are maintained over a lifetime and repaired following injury are fundamental questions in biology with a disruption to these processes underlying pathologies such as cancer and degenerative disorders. It is becoming increasingly clear that each tissue has a distinct mechanism to maintain homeostasis and respond to injury utilizing different types of stem/progenitor cell populations depending on the insult and/or with a contribution from more differentiated cells that are able to dedifferentiate to aid tissue regeneration. Peripheral nerves are highly quiescent yet show remarkable regenerative capabilities. Remarkably, there is no evidence for a classical stem cell population, rather all cell-types within the nerve are able to proliferate to produce new nerve tissue. Co-ordinating the regeneration of this tissue are Schwann cells (SCs), the main glial cells of the peripheral nervous system. SCs exist in architecturally stable structures that can persist for the lifetime of an animal, however, they are not postmitotic, in that following injury they are reprogrammed at high efficiency to a progenitor-like state, with these cells acting to orchestrate the nerve regeneration process. During nerve regeneration, SCs show little plasticity, maintaining their identity in the repaired tissue. However, once free of the nerve environment they appear to exhibit increased plasticity with reported roles in the repair of other tissues. In this review, we will discuss the mechanisms underlying the homeostasis and regeneration of peripheral nerves and how reprogrammed progenitor-like SCs have broader roles in the repair of other tissues with implications for pathologies such as cancer.
引用
收藏
页码:2203 / 2215
页数:13
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