Galectin-9 ameliorates immune complex-induced arthritis by regulating FcγR expression on macrophages

被引:54
作者
Arikawa, Tomohiro [1 ]
Watanabe, Kota [1 ]
Seki, Masako [1 ]
Matsukawa, Akihiro [2 ]
Oomizu, Souichi [1 ]
Sakata, Ken-mei [3 ]
Sakata, Atsuko [4 ]
Ueno, Masaki
Saita, Naoki [5 ]
Niki, Toshiro
Yamauchi, Akira
Hirashima, Mitsuomi [1 ]
机构
[1] Kagawa Univ, Fac Med, Dept Immunol & Immunopathol, Miki, Kagawa 7610793, Japan
[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pathol & Expt Med, Okayama, Japan
[3] Nishigohshi Hosp, Dept Rheumatol, Kumamoto, Japan
[4] Shokei Univ, Fac Sci Living, Dept Nutr Sci, Kumamoto, Japan
[5] Kumamoto Univ, Fac Med & Pharmaceut Sci, Dept Resp Med, Kumamoto, Japan
关键词
Galectin-9; Fc gamma RIIb; Fc gamma RIII; Macrophage; Immune complex; Arthritis; COLLAGEN-INDUCED ARTHRITIS; RHEUMATOID-ARTHRITIS; SUPPRESSOR-CELLS; RECEPTOR; INFLAMMATION; MICE; ACTIVATION; INDUCTION; PROMOTION; SYNOVIUM;
D O I
10.1016/j.clim.2009.09.004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Galectin-9 up-regulated Fc gamma RIIb expression of mouse peritoneal macrophages in vitro but down-regulated Fc gamma RIII expression. Galectin-9-treated macrophages stimulated with immune complexes (IC) produced less TNF alpha and IL-1 beta but more IL-10 than PBS-treated macrophages. Macrophage enhancing effects on IC-induced C5a and neutrophil chemotactic activity were also diminished for galectin-9-treated macrophages. In galectin-9-treated mice, the severity of IC-induced arthritis was reduced, as were pro-inflammatory cytokine levels in inflamed joints and serum C5a. Fc gamma RIIb expression of macrophages from galectin-9-treated mice was up-regutated, whereas Fc gamma RIII expression was down-regulated. Macrophages from galectin-9-treated mice produced less TNF alpha and IL-1 beta but more IL-10 than PBS-treated mice. Disease severity of galectin-9-transgenic mice was milder than wild-type mice, whereas that of galectin-9-deficient mice was exaggerated. Furthermore, macrophage Fc gamma RIIb expression in galectin-9-deficient mice was down-regutated, while Fc gamma RIII expression was up-regutated. These results suggest that galectin-9 suppresses IC-induced inflammation partly by regulating Fc gamma R expression on macrophages. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:382 / 392
页数:11
相关论文
共 34 条
[1]   Endogenous antigen presenting cell-derived IL-10 inhibits T lymphocyte responses to commensal enteric bacteria [J].
Albright, Carol A. ;
Sartor, R. Balfour ;
Tonkonogy, Susan L. .
IMMUNOLOGY LETTERS, 2009, 123 (01) :77-87
[2]   Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells [J].
Anderson, Ana C. ;
Anderson, David E. ;
Bregoli, Lisa ;
Hastings, William D. ;
Kassam, Nasim ;
Lei, Charles ;
Chandwaskar, Rucha ;
Karman, Jozsef ;
Su, Ee W. ;
Hirashima, Mitsuomi ;
Bruce, Jeffrey N. ;
Kane, Lawrence P. ;
Kuchroo, Vijay K. ;
Hafler, David A. .
SCIENCE, 2007, 318 (5853) :1141-1143
[3]   Galectin-9 accelerates transforming growth factor β3-induced differentiation of human mesenchymal stem cells to chondrocytes [J].
Arikawa, Tomohiro ;
Matsukawa, Akihiro ;
Watanabe, Kota ;
Sakata, Ken-mei ;
Seki, Masako ;
Nagayama, Megumi ;
Takeshita, Keisuke ;
Ito, Kanako ;
Niki, Toshiro ;
Oomizu, Souichi ;
Shinonaga, Rika ;
Saita, Naoki ;
Hirashima, Mitsuomi .
BONE, 2009, 44 (05) :849-857
[4]   Increased expression of Fcγ receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor α and matrix metalloproteinase [J].
Blom, AB ;
Radstake, TRDJ ;
Holthuysen, AEM ;
Slöetjes, AW ;
Pesman, GJ ;
Sweep, FGJ ;
van de Loo, FAJ ;
Joosten, LAB ;
Barrera, P ;
van Lent, PLEM ;
van den Berg, WB .
ARTHRITIS AND RHEUMATISM, 2003, 48 (04) :1002-1014
[5]   Destructive arthritis in the absence of both FcγRI and FcγRIII [J].
Boross, Peter ;
van Lent, Peter L. ;
Martin-Ramirez, Javier ;
van der Kaa, Jos ;
Mulder, Melissa H. C. M. ;
Claassens, Jill W. C. ;
van den Berg, Wim B. ;
Arandhara, Victoria L. ;
Verbeek, J. Sjef .
JOURNAL OF IMMUNOLOGY, 2008, 180 (07) :5083-5091
[6]  
Brand DD, 2004, METH MOLEC MED, V102, P295
[7]  
BROKER BM, 1990, SCAND J RHEUMATOL, V19, P123
[8]   Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors [J].
Clynes, R ;
Maizes, JS ;
Guinamard, R ;
Ono, M ;
Takai, T ;
Ravetch, JV .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (01) :179-185
[9]  
Combe Bernard, 2009, Best Pract Res Clin Rheumatol, V23, P59, DOI 10.1016/j.berh.2008.11.006
[10]   Galectin-9 induces maturation of human monocyte-derived dendritic cells [J].
Dai, SY ;
Nakagawa, R ;
Itoh, A ;
Murakami, H ;
Kashio, Y ;
Abe, H ;
Katoh, S ;
Kontani, K ;
Kihara, M ;
Zhang, SL ;
Hata, T ;
Nakamura, T ;
Yamauchi, A ;
Hirashima, M .
JOURNAL OF IMMUNOLOGY, 2005, 175 (05) :2974-2981