Association of Programmed Cell Death Factor 4 (PDCD4) with Hepatocellular Carcinoma and Smoking in a Chinese Male Population

被引：3

作者：

Jiang, Y. ^{[1
]}

Zhang, S. H-H ^{[1
]}

Han, G-Q ^{[2
]}

Qin, C. H-Y ^{[1
]}

机构：

[1] Shandong Univ, Dept Gastroenterol, Prov Hosp, Jinan 250021, Shandong, Peoples R China

[2] Shandong Univ, Dept Hepatol, Prov Hosp, Jinan 250021, Shandong, Peoples R China

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2009年 / 37卷 / 04期

关键词：

HEPATOCELLULAR CARCINOMA; TOBACCO SMOKING; PROGRAMMED CELL DEATH FACTOR 4 (PDCD4); SUPPRESSOR PROTEIN; CIGARETTE-SMOKE; TRANSLATION; LIVER; TRANSFORMATION; CANCER; DEGRADATION;

D O I：

10.1177/147323000903700424

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Programmed cell death factor 4 (PDCD4) is one of the genes that has been found to be up-regulated during apoptosis and loss of PDCD4 expression has been found in many kinds of progressive carcinomas. The objective of this study was to investigate the interactions between PDCD4 and smoking status in hepatocellular carcinoma. This case-controlled study included 68 Chinese male patients with hepatocellular carcinoma who were classified as smokers or nonsmokers according to their pack-years of smoking status. Samples were obtained from carcinoma and normal tissues and examined using Western blotting. The results indicated that levels of PDCD4 were significantly lower in hepatocellular carcinoma tissues compared with normal tissues and that, in normal tissue, PDCD4 levels in smokers were significantly lower than in non-smokers.

引用

页码：1179 / 1183

页数：5

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