On-chip mass spectrometric analysis in non-polar solvents by liquid beam infrared matrix-assisted laser dispersion/ionization

被引：5

作者：

Urban, Raphael D. ^{[1
]}

Fischer, Tillmann G. ^{[2
]}

Charvat, Ales ^{[3
]}

Wink, Konstantin ^{[1
]}

Krafft, Benjamin ^{[1
]}

Ohla, Stefan ^{[1
]}

Zeitler, Kirsten ^{[2
]}

Abel, Bernd ^{[3
]}

Belder, Detlev ^{[1
]}

机构：

[1] Univ Leipzig, Inst Analyt Chem, Linnestr 3, D-04103 Leipzig, Germany

[2] Univ Leipzig, Inst Organ Chem, Johannisallee 29, D-04103 Leipzig, Germany

[3] Leibniz Inst Oberflachenmodifizierung eV, Abt Funkt Oberflachen, Permoserstr 15, D-04318 Leipzig, Germany

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2021年 / 413卷 / 06期

关键词：

Microfluidics; IR-MALDI; Non-polar solvents; Reaction monitoring; PRESSURE CHEMICAL-IONIZATION; DESORPTION ELECTROSPRAY-IONIZATION; MALDI-MS; HPLC; DESORPTION/IONIZATION; WATER; MICROFLUIDICS; MICROREACTORS; BIOFLUIDS; COMPLEX;

D O I：

10.1007/s00216-020-03115-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

By the on-chip integration of a droplet generator in front of an emitter tip, droplets of non-polar solvents are generated in a free jet of an aqueous matrix. When an IR laser irradiates this free liquid jet consisting of water as the continuous phase and the non-polar solvent as the dispersed droplet phase, the solutes in the droplets are ionized. This ionization at atmospheric pressure enables the mass spectrometric analysis of non-polar compounds with the aid of a surrounding aqueous matrix that absorbs IR light. This works both for non-polar solvents such as n-heptane and for water non-miscible solvents like chloroform. In a proof of concept study, this approach is applied to monitor a photooxidation of N-phenyl-1,2,3,4-tetrahydroisoquinoline.

引用

页码：1561 / 1570

页数：10

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