Novel insights into circular RNAs in clinical application of carcinomas

被引：58

作者：

Rong, Dawei ^{[1
]}

Tang, Weiwei ^{[1
]}

Li, Zhouxiao ^{[1
,2
]}

Zhou, Jian ^{[3
]}

Shi, Junfeng ^{[4
]}

Wang, Hanjin ^{[1
]}

Cao, Hongyong ^{[1
]}

机构：

[1] Nanjing Med Univ, Nanjing Hosp 1, Dept Gen Surg, Changle Rd 68, Nanjing 210006, Jiangsu, Peoples R China

[2] Univ Hosp Munich, Dept Plast & Hand Surg, Munich, Germany

[3] Nanjing Med Univ, Nanjing Hosp 1, Dept Oncol Surg, Nanjing, Jiangsu, Peoples R China

[4] Nanjing Med Univ, Nanjing Hosp 1, Dept Oncol, Nanjing, Jiangsu, Peoples R China

来源：

ONCOTARGETS AND THERAPY | 2017年 / 10卷

关键词：

circular; targeted therapy; diagnosis; microRNA; noncoding RNA; PROFILING REVEALS; CELL-GROWTH; EXPRESSION; BIOMARKER; CANCER; IDENTIFICATION; PROLIFERATION; ABUNDANT;

D O I：

10.2147/OTT.S134403

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Circular RNAs (circRNAs), formed by nonsequential back-splicing of pre-messenger RNA (pre-mRNA) transcripts, have been widely concerned in recent years. With advances in high-throughput RNA sequencing (RNA-seq) technology, previous work has revealed that a large number of circRNAs, which are endogenous, abundant and stable in mammalian cells, may be involved in atherosclerotic vascular disease risk, neurological disorders, prion diseases and carcinomas. Remarkably, interaction between circRNAs and microRNA has already been observed to perform a significant role in a variety of cancers, including gastric cancer and colorectal cancer. Recent work has suggested that circRNAs may play critical roles in the initiation and development of cancers and could become potential new biomarkers for cancers. Herein, we review the current understanding of the roles of circRNAs in cancers and the potential implications of circRNAs in cancer-targeted therapy.

引用

页码：2183 / 2188

页数：6

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