Proliferation and osteogenic differentiation of human mesenchymal stem cells on zirconia and titanium with different surface topography

被引：33

作者：

Hirano, Tomoki ^{[1
,2
]}

Sasaki, Hodaka ^{[1
,2
]}

Honma, Shinya ^{[1
,2
]}

Furuya, Yoshitaka ^{[1
,2
]}

Miura, Tadashi ^{[1
]}

Yajima, Yasutomo ^{[1
,2
]}

Yoshinari, Masao ^{[1
]}

机构：

[1] Tokyo Dent Coll, Oral Hlth Sci Ctr, Div Oral Implants Res, Chiyoda Ku, 2-9-18 Misaki Cho, Tokyo 1010061, Japan

[2] Tokyo Dent Coll, Dept Oral & Maxillofacial Implantol, Chiyoda Ku, Tokyo 1010061, Japan

来源：

DENTAL MATERIALS JOURNAL | 2015年 / 34卷 / 06期

基金：

日本学术振兴会;

关键词：

Zirconia; Titanium; Surface topography; Mesenchymal stem cells; 3-dimensional surface characterization; OSTEOBLAST-LIKE CELLS; ACID-ETCHED SURFACE; IMPLANTS; SURVIVAL; ADHESION; MAXILLA; RATES;

D O I：

10.4012/dmj.2015-129

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The purpose of this study was to elucidate behavior of human mesenchymal stem cells (hMSCs) on yttria stabilized tetragonal zirconia polycrystals (TZP) and commercial pure titanium (CpTi) with different surface topography. Mirror-polished (MS), sandblasted with 150-mu m alumina (SB150) and SB150 acid-etched (SB150E) were prepared on TZP and CpTi. Proliferation, osteogenic differentiation of hMSCs was evaluated. The scanning electron microscopy showed that micro-and nano-topographies were created on both TZP and CpTi SB150E surfaces. The proliferation ability, ALP activity, expression of Runx2 on the both SB150E specimens was significantly higher than those on the other specimens. These results suggested that creation of micro- and nano-topographies on TZP and CpTi by blast and acid-etching may offer a promising method for enhancing the proliferation and differentiation of hMSCs in clinical application.

引用

页码：872 / 880

页数：9

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